Blood count and blood film changes in infection and inflammation

Question 1

what factors can affect normal blood count ranges

Answer 1

obesity, smoking, age, gender, ethnicity, excercise, geographical location

Question 2

what do you normally see in a blood film

Answer 2

neutrophils, eosiniphills, basophills, monocytes, erythrocytes, lymphocytes, platelets(thrombocytes), band neutrophils(not as devloped)

Question 3

what do lymphocytes originate from

Answer 3

pluripotent stem cell then lymphoid stem cell then lymphocyte

Question 4

how do all blood cells in blood arise apart from lymphocytes

Answer 4

pluripotent stem cell then from myeloid stem cell which then further differentiates accordingly

Question 5

what is function of neutrophils

Answer 5

phagocytosis fast acting

Question 6

what is role of eosinophils

Answer 6

attacks parasites allergic reaction

Question 7

what is basophil role

Answer 7

histamin and heparin relase

Question 8

what is function of monoctytes

Answer 8

phagocytosis slow response

Question 9

what would you expect to see in someone with epstein barr virus

Answer 9

sore throat, fatigues, enlarged cervical lymph nodes, anaemia and thrombocytopenia, lymphocytosis

Question 10

what can cause lymphocytosis

Answer 10

viral infection, bacterial infection, tissue infarction, stress related, cigarette smoking, if none of the above then haematological malignancy lymphomas etc

Question 11

what does lymphocytosis mean

Answer 11

Lymphocytosis (lim-foe-sie-TOE-sis), or a high lymphocyte count, is an increase in white blood cells called lymphocytes.

Question 12

what causes red cell agglutination

Answer 12

infection(HIV EBV, mycoplasma), Cll, waldenstroms, macroglobulinemia and autoimmune conditions SLE RA

Question 13

what does neutropenia mean

Answer 13

low level of neutrophils

Question 14

what does neutrophilia mean

Answer 14

high neutrophil count

Question 15

what would you expect to see in someone with bacterial sepsis

Answer 15

neutrophilia, toxic granulation and left shift, anaemia, leukoerythroblastic, thrombocytopenia or thrombocytosis, haemolyisis

Question 16

what can cause neutrophilia

Answer 16

infection, tissue damage(trauma surgery, burn), tissue infarction, acute chronic inflammation, medications corticosteroids adrenaline lithium, haematological malignancies

Question 17

what do you expect to see in person with malaria blood test clinical findings

Answer 17

fever, drowsy, come back from tropical country, anaemic, neutrophilia, thrombocytopenia, lymphopenia or lymphocytosis, monocytosis

Question 18

if individual has tb what underlying condition is it important to be vigilant for

Answer 18

HIV