Abnormal LFTs and Non Alcoholic Fatty Liver Disease Flashcards
what do liver function tests consist of
bilirubin, alkaline phosphatase, alanine transamiase, gamma gt
what indicates hepatitis(inflamed liver in lft)
raised alt or ast
patients lft shows raised alkaline phosphatase and raised gamma gt what does this suggest
cholestasis, obstructive
what normally causes cholestasis
obstruction of bile duct or small bile ducts
list the causes of abnormal liver enzymes
Alcohol • Medications • Non-alcohol Fatty Liver Disease (NAFLD) • Space occupying lesions • Viral Hepatitis – Chronic hepatitis B and C • Haemochromatosis • Rarer causes – Autoimmune hepatitis – Primary Biliary Cirrhosis – Alpha-1-antitrypsin deficiency – Wilson’s disease – Coeliac disease – Sero-negative hepatitis
a patient has present with an abnormal liver function test results what investigation would I want next
FBC,INR, U+E, lipids, imaging ultra dopplers, immunoglobins and auto antibodies
a individual is found to be hepatitis A igm positive what does this suggest
acute episode of hep a
a individual is found to be hepatitis A igg positive what does this suggest
previous exposure or vaccine
if you want to see if the patient has acute hepatitis B what immunological test should I do
test for core IGM antibody
if I want to see if the patient is immune to hep b what immunological test should I do
igg surafce antibody
if patient test positive for hep b surface antigen what does this mean
they have hep b refer!!
core igg for hep b can tell us..
if patient has ever been exposed to hep b
whta drug is used to treat hep c
Harvoni is indicated for the treatment of chronic hepatitis C (CHC) in adults
is hep b curable
no but we can indefinetley control the virus
how do you diagnose haemochromatosis
raised ferritin, hfe gene, lver biopsy and hepatic iron estimation, hepatic iron index and hll
