Inflammatory/Auto-immune skin disease

Question 1

patient presents with intermittent red scaly skin, stress causing flare ups, what is it likely to be

Answer 1

psoriasis

Question 2

what can pre dispose someone to psoriasis

Answer 2

pharyngitis, emotional stress, physical trauma, drugs such as nsaids, beta blockers, hiv

Question 3

what areas can psoriasis affect

Answer 3

nails changes such as pitting, chronic plaque psoriasis, flexural psoriasis under the armpits, genital psoriasis

Question 4

what can genital psoriasis be misdiagnosed as

Answer 4

candida/ fungal issue

Question 5

what are the most common psoriasis symptoms

Answer 5

thick red skin, itching, pain, scaling

Question 6

how does psoriasis impact individual quality of life

Answer 6

can cause depression, can cause ppl to quit work, feel unattractive, they become financially distressed as a result

Question 7

what can inflammation due to psoriasis increase the risk of

Answer 7

cardiovascular disease

Question 8

what is Dactylitis

Answer 8

whole finger is swollen can be toe also

Question 9

what is psoriasis arthiritis

Answer 9

Psoriatic arthritis is a type of arthritis that develops in some people with the skin condition psoriasis. It typically causes affected joints to become inflamed (swollen), stiff and painful. Like psoriasis, psoriatic arthritis is a long-term condition that can get progressively worse.

Question 10

name some drug treatments available for psoriasis

Answer 10

anti il17, anti il 12/23 anti tnf a

these are monoanticlonal antibodies

Question 11

what does erythroderma mean

Answer 11

90 per cent of the body is involved “red from head to toe”

Question 12

what issues are associated with erythroderma

Answer 12

temp regulation, fluid balance, hypovolaemia, hypoalbuminemia

Question 13

what causes erythroderma

Answer 13

psoriasis, drugs (no one cause), infections (staph), eczema, blistering diseases

Question 14

what is atopic dermatitis

Answer 14

Chronic, relapsing, skin disorder usually
associated with a personal or family history
of atopic disease
• Atopic march
• Intense pruritus

Question 15

why is diurnal variation important to help diagnose autoimmune diseases

Answer 15

because cortisol is lower at night so less immune system supression so condition if autoimmune will worsen

Question 16

what factors contribute to atopic dermatitis

Answer 16

environmental, genetic, immunological factors(abnormal th2 immune response ige)

Question 17

why is the filaggrin gene important to atopic dermatitis

Answer 17

mutations in this gene cause deficiency in keratohyaline granules which weakens the horny layer structure so more allergens can get in. this triggers th2 response

Question 18

young child with a red rash on cheeks and some yellowish tinges of pus what is it

Answer 18

more likely to be eczema than psoriasis because the child is so young. also the cheeks is typical eczema area in young kids. yellowish suggests it is infected eczema caused by staph aureus

Question 19

if someone has eczema with vesicles that look fluid filled what is the infection likely to be

Answer 19

herpes virus, needs urgent treatment, to protect eyes and from meningitis

Question 20

is atopic dermatitis an acute disease with recurrent flares

Answer 20

no, it is a Chronic disease with recurrent flares

Question 21

what can hsv do to eczema

Answer 21

Herpes simplex infection may result in eczema

herpeticum

Question 22

how is atopic dermatitis treated

Answer 22

Skin	care:	emollients,	baths	
• Topical	steroids	(weak	Vs	potent)	
• Wet	dressings	
• Avoidance	of	environmental	factors	that	
trigger	disease	
• Severe	cases:	PUVA,	UVB,MTX,	azathioprine,	
mycophenolate	mofetil,	cyclosporine	
• Biologics