Inflammatory/Auto-immune skin disease Flashcards
patient presents with intermittent red scaly skin, stress causing flare ups, what is it likely to be
psoriasis
what can pre dispose someone to psoriasis
pharyngitis, emotional stress, physical trauma, drugs such as nsaids, beta blockers, hiv
what areas can psoriasis affect
nails changes such as pitting, chronic plaque psoriasis, flexural psoriasis under the armpits, genital psoriasis
what can genital psoriasis be misdiagnosed as
candida/ fungal issue
what are the most common psoriasis symptoms
thick red skin, itching, pain, scaling
how does psoriasis impact individual quality of life
can cause depression, can cause ppl to quit work, feel unattractive, they become financially distressed as a result
what can inflammation due to psoriasis increase the risk of
cardiovascular disease
what is Dactylitis
whole finger is swollen can be toe also
what is psoriasis arthiritis
Psoriatic arthritis is a type of arthritis that develops in some people with the skin condition psoriasis. It typically causes affected joints to become inflamed (swollen), stiff and painful. Like psoriasis, psoriatic arthritis is a long-term condition that can get progressively worse.
name some drug treatments available for psoriasis
anti il17, anti il 12/23 anti tnf a
these are monoanticlonal antibodies
what does erythroderma mean
90 per cent of the body is involved “red from head to toe”
what issues are associated with erythroderma
temp regulation, fluid balance, hypovolaemia, hypoalbuminemia
what causes erythroderma
psoriasis, drugs (no one cause), infections (staph), eczema, blistering diseases
what is atopic dermatitis
Chronic, relapsing, skin disorder usually
associated with a personal or family history
of atopic disease
• Atopic march
• Intense pruritus
why is diurnal variation important to help diagnose autoimmune diseases
because cortisol is lower at night so less immune system supression so condition if autoimmune will worsen
what factors contribute to atopic dermatitis
environmental, genetic, immunological factors(abnormal th2 immune response ige)
why is the filaggrin gene important to atopic dermatitis
mutations in this gene cause deficiency in keratohyaline granules which weakens the horny layer structure so more allergens can get in. this triggers th2 response
young child with a red rash on cheeks and some yellowish tinges of pus what is it
more likely to be eczema than psoriasis because the child is so young. also the cheeks is typical eczema area in young kids. yellowish suggests it is infected eczema caused by staph aureus
if someone has eczema with vesicles that look fluid filled what is the infection likely to be
herpes virus, needs urgent treatment, to protect eyes and from meningitis
is atopic dermatitis an acute disease with recurrent flares
no, it is a Chronic disease with recurrent flares
what can hsv do to eczema
Herpes simplex infection may result in eczema
herpeticum
how is atopic dermatitis treated
Skin care: emollients, baths • Topical steroids (weak Vs potent) • Wet dressings • Avoidance of environmental factors that trigger disease • Severe cases: PUVA, UVB,MTX, azathioprine, mycophenolate mofetil, cyclosporine • Biologics
