Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Inflammation > SLE > Flashcards

SLE Flashcards

1
Q

in someone with SLE what is a typical esr and crp reading

A

esr 100, crp is 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

describe whate you would expect to find in a person with sle when looking at blood cells and complement

A

cytopenia(low blood cells) and low complement c3/c4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

list the targets of autoantibodies in SLE

A

dna, nucleosomes, C1q, a actinin, Sm, NDMA receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

systemic lupus erthematosus is a multi system autoimmune is this statement true

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what environmental factors can trigger sle

A

sunlight, drugs smoking and viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how do genes contribute to SLE

A

the genes cause defective apoptosis, which creates autoantigens, stimulates immune response against self

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what factors contribute to SLE as it’s direct cause is unknown

A 
Female hormones
• Genetics
• Drugs
• Environmental factors
• Ethnic origin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

who is most likely to get sle

A

females and individuals of african and asian

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

name some symptoms of sle in women aged 15-45

A

malaise, fatigue, hair loss, arthritis, aches and pains, mouth ulcers, rashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the types of cutaneous lupus

A

discoid lupus(coin shaped lesions) and subacute acute cutaneous lupus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

sle lesions feel cold to touch and are on the hands and feet what are they called

A

chillblain lupus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

lupus can also cause lupus vasculitits name examples of small vessel vasculitis

A
  • Splinter haemorrhages
  • Digital infarcts
  • Palpable purpura
  • Vasculitic ulcers
  • Urticarial vasculitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

medium or large vessel vasculitis can result in …

A

Digital ischaemia/gangrene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

course of sle follows three stages, pre clinical, clinical disease, comorbididties. state what each stage is represented by

A

pre clinical just autoantibodies, clinical disease involves organs and flare ups and damage.

comorbidities comes last and involves infections, malignancies and atherosclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what can peripherial vascular disease cause in SLE

A
  • Critical limb/digital ischemia
  • Gangrene
  • Amputations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how can lupus affect the pulmonary system

A

lupus pnemonitis or lupus serositis

17
Q

lupus can affect the heart causing pericarditis how is it treated

A

Common
Rapidly resolves with corticosteroids
Rarely leads to tamponade

18
Q

list the ways in which lupus can effect the cardiac system

A

pericarditis, endocarditis,myocarditis,

19
Q

name some features of Neuropsychiatric lupus

A
  • Psychosis
  • Seizures
  • Strokes
  • Psychological disorders
  • Transverse myelitis
20
Q

SLE can affect the kidneys cause lupus nephritis what are some of the presenting features

A 
Asymptomatic proteinuria
Nephrotic syndrome
Renal failure
Rapidly progressive glomerulonephritis
Dysmorphic / fragmented red cells
Granular casts
21
Q

Because SLE is a chronic condition what three things should be kept in mind when assessing it

A

disease activity, quality of life and damage

22
Q

how do you assess disease activity in sle

A

Bilag, SLEDAI

23
Q

how do you assess quality of life in lupus

A

LupusQoL

SF36, HAQ

24
Q

what are the aims of sle treament

A

prevent disease flares, avoid long term damage, Induction and maintenance of durable remission
-Minimise toxicity and treatment related damage

25
Q

how can you treat sle

A

first off avoiding sun, using sunscreen, topical steroids, stop smoking and analgesics (not NSAIDS contra), then cortico steroids after these steps, then after that monoclonal antibodies such as belimumab

26
Q

why should caution be used when treating sle with corticosteroids

A

Excessive doses: 1mg/kg/day NOT evidence based!
Major contributor to damage
Use the lowest effective dose for
the shortest period of time

27
Q

name some antimalarials used to treat sle

A

Hydroxychloroquine
• Mepacrine/Quinacrine
• (Chloroquine)
• Combination antimalarials

28
Q

indivudal has been given sle intial sle treatment but has renal issues and fertility issues what treatments should they be given

A

severe treatment cyclophosphamide,Mycophenolate , iv methylprednisolone

29
Q

what is The Antiphospholipid syndrome in SLE

A

antiphospholipid antibodies which can cause thrombosis or pregnancy morbidity

30
Q

cns lupus can cause strokes and tias how can we treat this

A

anti coagulation

31
Q

how do you treat systemic sclerosis form sle in early stage

A

Treatment

• Early: low dose steroids immunosuppressives

32
Q

how do you treat systemic sclerosis form sle in late stage

A

Late: Symptomatic Rx

BP control

Inflammation (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions