acute phase response Flashcards
briefly summarize what happens happens in the inflammatory reaction during the acute phase
vasodilation of vessels, capillary wall permeability increases, transmigration of cells into target tissue, changes of bio synthetic, metabolic and catabolic profile of many organs, immune system activation
what can cause inflammation
bacteria, trauma, sepsis, burns, pancreatitis, autoimmune disorders.
define acute phase response
general term for the systemic and metabolic changes that occur within hours of an inflammatory stimulus
what are the local proinflammtory cytokines (main ones normally released)
tnf a, il6, il1,
name biological processes in acute phase response KEY TERMS
leukocytosis, complement activation, opsonisation, clotting, protease inhibition
In systemic response in acute phase reaction what systems /areas
liver, metabolic, haematoglic, neuroendocrine, biochemical
what inflammatory mediators cause fever
tnf-a and il1
what inflammatory mediators cause stress hormone release
tfna il1
what inflammatory mediators cause synthesis of il6 and il8
tnfa and il1
what stimulates release of acute phase reactants such as crp
cytokines especially il6
what cytokines are responsible for decreasing the inflammatory response
il10 and il4 anti inflammatory
what are acute phase proteins APP
large groups of biochemical and functionally unrelated proteins whose plasma conc decrease and increase in repsonse to injury, ACUTE infections, burns or chronic inflammation.
why are app useful in tests
APPs are ideal biomarkers of inflammation
where are the APP produced
in the liver
name the apps
fibrinogen, crp, serum amyloid protein, haptoglobin
