Vinca Alkaloids

Question 1

MOA of Vinca Alkaloids

Answer 1

INHIBIT MICROTUBULE FORMATION during the M phase of the cell cycle

Question 2

What is a common side effect of vinca alkaloids

Answer 2

neuropathies

Question 3

List vinca alkaloid drugs

Answer 3

Vincristine
Vinblastine
Vinorelbine

Question 4

Which vinka alkaloid causes more CNS toxicity

Answer 4

vinCristine

Question 5

which vinca alkaloid(s) causes more Bone Marrow suppression

Answer 5

vinBlastine and vinorelBine

Question 6

Which vinca alkaloid is a Major Cyp3A4 substrate

Answer 6

vinctristine

Question 7

List the safety concerns for vinca alkaloids

Answer 7

1. Peripheral neuropathy (CNS)
2. Autonomic neuropathy (constipation)

Question 8

What would happen if given a vinca alkaloid INTRATHECALLY instead of IV

Answer 8

PARALYSIS and DEATH if given intrathecally

Question 9

What prevention can be used to ensure vinca alkaloids are given IV and not intrathecally

Answer 9

1. prepare in SMALL IV BAG (PIGGYBACK)
2. label products to prevent accidental intrathecal administration

Question 10

To prevent peripheral neuropathy, what dose limit should be placed on vinCristine

Answer 10

Limit single vinCristine doses to 2 mg (regardless of BSA-calculated dose)