Taxanes

Question 1

MOA of Taxanes

Answer 1

INHIBIT the DEPOLYMERIZATION of TUBULIN (which stabilizes microtubules) during the M phase

Question 2

List Taxane drugs

Answer 2

PACLITAXEL
Docetaxel
Cabazitaxel (Jevtana)

Question 3

Special preparations for Taxane IV products

Answer 3

1. Use NON-PVC bag and tubing (all)
2. Use 0.22 MICRON FILTER (for cabazitaxel and paclitaxel; except for the albumin bound paclitaxel (Abraxane))

Question 4

Safety concerns for Taxanes

Answer 4

1. Peripheral neuropathy
2. Hypersensitivity reactions

Question 5

what is a unique safety concern for Docetaxel

Answer 5

Severe fluid retention

Question 6

What prevention method can be used for hypersensitivity of Taxane drugs

Answer 6

PREMEDICATION w/ a systemic steroid (dexamethasone), Benadryl and an H2RA (famotidine)

Question 7

what treatment options are there for hypersensitivity relating to Taxane drugs

Answer 7

1. Stop/interrupt therapy; do NOT rechallenge if reaction is severe
2. Symptomatic care (ex: oxygen, epinephrine)

Question 8

Q. what prevention can be used for Docetaxel and its safety concern of severe fluid retention
Q. Tx

Answer 8

1. Premedication with a systemic steroid (dexamethasone)
2. Symptomatic care (ex: diuretics)