Anthracyclines

Question 1

MOA of anthracyclines

Answer 1

1. Intercalation into DNA
2. INHIBITION OF TOPOISOMERASE 2
3. Creation of oxygen-free radicals that damage cells

Question 2

Anthracycline drugs

Answer 2

Doxorubicin (Adriamycin)
Daunorubicin

Mitoxantrone

Question 3

Safety concerns for doxorubicin

Answer 3

1. CARDIOTOXICITY
2. RED discoloration of body fluids

Question 4

To prevent cardiotoxicity what is the TOTAL LIFETIME CUMULATIVE DOSE

Answer 4

450 - 550 mg/m2

Question 5

When the doxorubicin cumulitive dose is ≥ 300 mg/m2 with planned continued treatment, what chemoprotectant should be used

Answer 5

DEXRAZOXANE

Question 6

At what cumulative dose should the chemoprtoectant- Dexrazoxane be used if treatment will still be used

Answer 6

≥ 300 mg/m2

Question 7

When should treatment of doxorubicin be stopped

Answer 7

When the cumulative dose reaches 450 - 550 mg/m2, tx must be stopped

(the lower end of the dose range is used if CV risk or previous mediastinal radiation)

Question 8

Q. What should be monitored before and after tx with doxorubicin
Q. using what

Answer 8

1. LVEF
2. Echocardiogram or MUGA scan

Question 9

Which anthracycline has a safety concerns specifically for BLUE discoloration of bodily fluids

Answer 9

Mitoxantrone