Topoisomerase 2 Inhibitors

Question 1

MOA of topoisomerase 2 inhibitors

Answer 1

BLOCK the coiling and uncoiling of the dsDNA but during the G2 phase of the cell cycle

Question 2

List topoisomerase 2 inhibitor drugs

Answer 2

Etoposide

Question 3

Q. What safety concerns are there for Etoposide
Q. What should be monitored

Answer 3

1. Infusion- related hypOtension
2. Vital signs (BP)

Question 4

How do you prevent infusion-related hypOtension with Etoposide

Answer 4

Infuse over at least 30 - 60 minutes

Question 5

What is the treatment for infusion-related hypOtension with Etoposide

Answer 5

1. IV hydration
2. Decrease infusion rate upon reinitiation