Platinum based compounds Flashcards
List platinum compound agents
Cisplatin
Carboplatin
Oxaliplatin
Which platinum compound has the greatest incidence of neurotoxicity and ototoxicity
Cisplatin
What are the safety concerns for platinum compounds
- Hypersensitivity
- Nephrotoxicity
- Ototoxicity
- Peripheral neuropathy
What is a unique safety concerns specifically for Oxaliplatin
Acute sensory neuropathy EXACERBATED BY COLD
What prevention is implemented when on Oxaliplatin
AVOID COLD EXPOSURE (cold temps, consumption of cold foods/drinks)
Prevention of Nephrotoxicity and the specific prevention measures for Cisplatin
- Adequate HYDRATION
- AMIFOSTINE (Ethyol)- Chemoprotectant that reduces cumulative renal toxicity w/Cisplatin
- Limit Cisplatin dose per cycle to ≤ 100 mg/m2
what chemoprotectant is used to prevent nephrotoxicity in Cisplatin
Amifostine (Ethyol)
What is Cisplatin’s limit dose per cycle to prevent nephrotoxicity
limit Cisplatin to ≤ 100 mg/m2
To monitor for ototoxicity, what should be done at baseline and after treatment
AUDIOGRAM
How do you prevent ototoxicity
avoid concomitant ototoxic meds (ex: aminoglycosides)
Q. Which platinum agent is the only one that does not use BSA to calculate dose
Q. What formula is used
Q. State the formula
- Carboplatin
- Calvert formula
- (Target AUC) x (GFR + 25)
What is the AUC range for Carboplatin
2 - 8 mg/mL x min
What may be used to calculate carboplatin if GFR is not available
CrCl
what is GFR commonly capped at
125 mL/min/1.73 m2
