Antidotes, Rescue drugs, Chemoprotectants Flashcards
1
Q
what chemoprotectant is used for alkylating agents cyclophosphamide and ifosfamide for hemorrhagic cystitis
A
Mesna
2
Q
what chemoprotectant is used for the platinum agent Cisplatin for nephrotoxicity
A
Amifostine (Ethyol)
3
Q
what chemoprotectant is used for anthracycline agent doxorubicin for cardiotoxicity
A
Dexrazoxane
(for select patients)
4
Q
what is the ANTIDOTE for pyrimidine analog agents 5-FU and capecitabine for DPD
A
Uridine Triacetate (Vistagard)
5
Q
what “RESCUE” drug(s) can be given to the folate antimetabolite, MTX for PREVENTION of nephrotoxicity and prevention/ treatment for GI toxicity
A
Leucovorin or levoleucovorin
6
Q
what ANTIDOTE can be given to the folate antimetabolite, MTX for TREATMENT of nephrotoxicity
A
Glucarpidase (Voraxaze)
