Vessels and atherosclerosis

Question 1

in elastic arteries, elastic fibers alternate between smooth muscle cells in ____

Answer 1

media

Question 1

___ migrate to intima and proliferate in normal repair and atherosclerosis

Answer 1

sooth muscle cells

Question 3

two basic types of damage from athersclerosis

Answer 3

stenosis, aneurysm formation

Question 4

mockenberg arteriosclerosis

Answer 4

calcfic deposits in media (and internal elastic lamina)

no obstruction to blood flow

usually insignificant

Question 5

____ arterioles have no elastica

Answer 5

terminal

Question 6

in muscular arteries, elastic fibers limited to ___

Answer 6

internal and external elastic lamina

Question 7

pathogenesis of atherosclerosis (4)

Answer 7

1. Chronic inflam. response of art. wall in response to injury
2. Chronic endothelial injury/dysfxn > Increased permeability and luekocyte adhesion
3. Inflammation > adhesion molecules, monocyte adhesion, Tcell cytokines + fibrogenic mediators
4. Infection

Question 8

in lipid incorporation into vessels, ____ is taken up by ___ via scanvenger receptors

Answer 8

oxLDL taken up by macrophages

(which then activates them)

Question 9

factors contributing to throbosis

Answer 9

shear stress

high LDL

smoking

Question 10

atherosclerosis

Answer 10

hardening of elastic and large/medium muscular arteries

Question 11

___ smooth muscle cells cannot contract

Answer 11

intimal

Question 12

anteriolosclerosis

Answer 12

hardening of small arteries and arterioles