Cardiac Cell Bio Flashcards
surrounds myofibrils in vessel myocytes
sarcoplasmic reticulum
intercalated discs
sarcomlemma specializations enabl cardio myocytes to work as a unit, corssing myocytes in a staircase fashion
role of transverse intercalated discs
transmit force, made up of fascian adherens (Ncadherins) and desmosomes
role lateral intercalated discs
cell cell signaling - gap junctions (nexus) and some desmosomes
Phase 2 of action potential (following depolarization to T-tubules)
L-type 1.2 > Ca influx
Ryanodine receptors in SR >>>> Ca
(CICR)
in contraction, Ca binds ____ > ____ moves as myosin head activated by ATP hydrolysis and binds ___
Ca binds torponin-C > tropomyosin moves as myosin head activated by ATP hydrolysis and binds actin
___ filaments mvoe to shorten the sacromere
thin filaments
(A band stays the same, I band shortens)
process of relaxation
L type channels inactivate > Ca sequestered into SR via SERCA
enhanced contractile force mechanism of B-adrenergic stim
phosphorylation > L type Ca channel > Ca influx increased
relaxation mechanism of beta-adrenergic stim
phosphorylation > phospholamban in SR > increased SR Ca uptake > relaxation
in atria, membrane bound granules contain
atrial natriuretic factor
____ contains purkinje myocytes specialized for conduction
Bundle of His
most abundant heart cell type
cardiac fibroblasts
heart lacks the ___- cells that allow skeletal muscle to regenerate
statelite cells
adult stem cells identified via expression of
c-Kit
