Infectious Agents of HD

Question 1

mechanism rifampin

Answer 1

inhibits rnapolymerase to prevent gene expression

not for monotherapy

Question 3

beta lactam resistance most common in

Answer 3

gram positive (Strep and MRSA)

Question 4

means of binding to endocardium, viridans streptococci

Answer 4

adhesions that mediate attachemnt to paltelets and fibrin

dextran

Question 4

mechanism betalactam antibiotics

Answer 4

block petidoglycan crosslinking at L-ala-D-ala

Question 4

mechanism Daptomycin

Answer 4

disrupt cell membrane/ cell wall

(maintains effectiveness against resistant bacteria)

Question 4

mechanism of resistance to gentamicin

Answer 4

modification of antibiotc to prevent binidng 30S subunit of ribosome

Question 5

most common microbioata of infectious endocarditis (4)

Answer 5

Staph A

Coag neg Staph (epidermidis) (skin)

Viridans strep (oral)

Enteroccoi (gi)

Question 6

mechanism vancomycin

Answer 6

glyopeptide

bind D-ala-D-ala to block PBP from catylizing transglyocsylation of petiodglycans

(effective on Gram positives, not negatives)

Question 8

means of binding endocardium S aureus

Answer 8

fibrinogen binding adhesions

Question 9

mehcnaism Gentamicin

Answer 9

aminoglycoside

bind 30S ribosomal subunit irreversible to cause misreading

paired with cell wall agent to increase permeability

Question 10

mechanism of resistance to vancomycin

Answer 10

modification of target to D-Ala-D-lac to prevent binding

via transposons transfered betwen bacteria