Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cardiovascular > peripheral vascular disease > Flashcards

peripheral vascular disease Flashcards

1
Q

common infectious causes of aneurysm

A

Mycotic aneurysm (mucormycosis)

Syphillis (Treponema pallidum)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

treatment giant cell / temporal arteritis

A

high dose steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

histology Microscopic polyangiitis (leukocytoclastic vasculitis)

A

fibrinoid necrosis,

neutrophils

nuclear dust (Karyorrhexis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

clinical features of thoracic aortic aneurysm

A

mediastinum encroachment: tracheal/esophogeal compression,

bone erosion,

cough (larygneal nerve)

Heart failure due to insuficient aortic valve, aortic rupture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pressentation, pathogensis, vessels

Takayasu Arteritis

A

Pulseless disease (UE)

ocular disturbances

Japanese women

granulomatous inflammation of aortic arch+ branches

pulmonary, coronary, renal artery pos.

autoimmune etiology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

presentation, pathogenesis, vessels Churg Strauss

A

palpable purpura, GI bleeding, Renal impairment, Cardiomyapthy, MPO ANCA +

possible hyper-response to allergic stim

Small Vessel vasculitis associated with - asthma, allergic rhinitis, peripheral eosinophilia, necrotizing granulomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

presentation aotic dissection

A

stabbing or tearing anterior chest pain radiating to back

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

most common location of aortic dissection

A

ascending aorta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

aortic disection = ____ tear within 10 cm of ___

A

intimal tear within 10 cm of aortic valve

(dissection palce between middle and outer thirds of wall in media0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ehlers dalos vs marfans

A

ehlers danlos - type iII collagen

marfans- fibrillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

presentation, pathogenesis, vessels

Microscopic Polyangiitis (Leukocytoclastic Vasculitis)

A

Clinical depends on vascular bed (hemoptysis, hematuria, protinuria, abd pain and muscle pain or bleeding, cutaneous purpura)

Arterioles, cappillaries, venules of Skin, mucous membranes, **lungs, kidneys **brain, heart, GIT, muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Thromboangiitis Obliterans (Buerger)

A

smokers,

Painful ischemia, gangrene of limbs

inflammation and thrombosis of medium-small muscular arteries and secondarily, nerves and veins. Tibial and radial artery esp.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Raynaud phenom

A

prosymall pallor or cyanosis of fingers, toes, nose, easrs

healthy young woman

recurrent vasospasm, no strucutral changes in arterial wall until late.

(can be secondary to arterial insufficiency due to SLE, SS, atheroscloriss, beurger)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

presentation, pathogenesis, vessels

wegner granulomatosis

A

PR3-ANCA positive

40yo Pneumonitis, Sinusitis, Nasopharyngeal ulcerations, Renal Dease

necrotizing vasculitis > granulomas of lung or UR+ENT (likely cell mediated hypersensitivitiy)

vasculitis of small-medium in lung and UR tract

Glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

histology Kawaski’s

A

necrosis and inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

savular vs fusiform anyeurism

A

sacular buldges out one side, unilateral

fusiform: uniform expansion of the vessel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

histology Takayasu ateritis

A

lymphocytes, giant cells

collagenous fibrosis

15
Q

most common location of aortic anyeurism

A

abdominal aorta

15
Q

presentation abdominal aortoci aneurysm

A

pulsatile abdominal mass

16
Q

histology Polyarteritis nodosa

A

Necrosis with karorrhexis

transmural, full thickness inflammation

17
Q

Presentation, pathogenesis, vessels

Polyarteritis nodosa

A

Young aadults (30% Hep B ag)

No ANCA

Aneurysms

Rapidly accel HTN, abdominal pain + blood stool

peripheral nephritis

Renal and viceral arteries (spares lungs)

systemic transmular necrotizing inflammation of small or med muscular arteries

18
Q

histology of giant cell arteritis

A

granulomatous inflammation of inner half of media around internal elastic lamina

destruction of internal elastic lamina

multinucleated giant cells

19
Q

Presentation, pathogenesis, vessels

Polyarteritis nodosa

A

Young aadults (30% Hep B ag)

No ANCA

Aneurysms

Rapidly accel HTN, abdominal pain + blood stool

peripheral nephritis

Renal and viceral arteries (spares lungs)

systemic transmular necrotizing inflammation of small or med muscular arteries

21
Q

ANCA

two main patters

A

auto-antibodies agasint granule enzymes of neutrophils

PR3-ANCA - Wegner granulomatosis

MPO-ANCO - microscopic polyangitis and Churg Strauss syndrome

22
Q

presentation, pathogenesis, vessels Churg Strauss

A

palpable purpura, GI bleeding, Renal impairment, Cardiomyapthy, MPO ANCA +

possible hyper-response to allergic stim

Small Vessel vasculitis associated with - asthma, allergic rhinitis, peripheral eosinophilia, necrotizing granulomas

24
Q

underlying excessive connective tissue degradations often due to

A

increased MMP

decreased inhibitors of MMP (TIMP)

polymorphisms off MMP or TIMP in the presence of inflammation predispose

25
Q

Presentation, pathogenesis, vessels

Kawasaki’s

A

mucocutenous lymph node syndrome, mucous membrane inflam.

anyeurisms (resembles PAN)

Large medium and small arteries

**Often coronary **with aneurysm formation

26
Q

hemopericardium in aortic dissection

A

blood disects thouhg media, proximally, filling pericardial sac

(may also rupture into pleural or peritoneal cavities)

27
Q

in aortic dissection secondary to marfan syndrome, _____ causes connective tissue weakness, appearing as pools of blue mucinous ground substance disrupting elastic fibers

A

cystic medial necrosis

29
Q

pathogenesis of immune complex mediated vasculitis

A

SLE (DNA and anti-DNA complexes)

Drug Hypersensitivity

HBsAg and anti HBSsAg

30
Q

layer impact aneurysm

A

loss of SMCs

thickening of intima due to atherosclerosis > ischemia of inner media

systemic HTN > narrows vasa vasorum leading to ischemia of outer layers

31
Q

morpolohy of aortic aneurysm

A

thinning and destruction of media

mural thrombus

saccular or fusiform

inflammatory or mycotic

33
Q

Atheroscleorsis likely to impact -____ for anyeurism

while HTN is more likely to impact ____

A

Atherosclerosis - abdominal aorta

HTN - ascending aorta

34
Q

presentation, pathogenesis, vessels

wegner granulomatosis

A

PR3-ANCA positive

40yo Pneumonitis, Sinusitis, Nasopharyngeal ulcerations, Renal Dease

necrotizing vasculitis > granulomas of lung or UR+ENT (likely cell mediated hypersensitivitiy)

vasculitis of small-medium in lung and UR tract

Glomerulonephritis

35
Q

presentation, pathogenesis, vessels

Microscopic Polyangiitis (Leukocytoclastic Vasculitis)

A

Clinical depends on vascular bed (hemoptysis, hematuria, protinuria, abd pain and muscle pain or bleeding, cutaneous purpura)

Arterioles, cappillaries, venules of Skin, mucous membranes, **lungs, kidneys **brain, heart, GIT, muscles

36
Q

Pressentation, pathogensis, vessels

Takayasu Arteritis

A

Pulseless disease (UE)

ocular disturbances

Japanese women

granulomatous inflammation of aortic arch+ branches

pulmonary, coronary, renal artery pos.

autoimmune etiology

37
Q

Presentation, pathogenesis, vessels

Kawasaki’s

A

mucocutenous lymph node syndrome, mucous membrane inflam.

anyeurisms (resembles PAN)

Large medium and small arteries

**Often coronary **with aneurysm formation

38
Q

other mechanism of vasculitis pathogenesis

A

antibodies to endothelial cells (Kawaski’s)

39
Q

Thromboangiitis Obliterans (Buerger)

A

smokers,

Painful ischemia, gangrene of limbs

inflammation and thrombosis of medium-small muscular arteries and secondarily, nerves and veins. Tibial and radial artery esp.

40
Q

Pathogensis, vessels, and presentation

Giant Cell / Temporal Arteritis

A

most common form

Aorta+branches, esp Temp and vertebral

50yo, painful Temporal artery

diplopia, vision loss

headache

increased ESR

41
Q

Pathogensis, vessels, and presentation

Giant Cell / Temporal Arteritis

A

most common form

Aorta+branches, esp Temp and vertebral

50yo, painful Temporal artery

diplopia, vision loss

headache

increased ESR

Cardiovascular (39 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions