Vessels Flashcards
Blood Volume Distribution
Systemic Veins 64% Systemic Arteries 13% Pulmonary vessels 9% Heart 7% Systemic Capillaries 7%
What is the Adventitia of the arterial wall composed of?
Strong fibrous tissue
What is the Media of the arterial wall composed of?
smooth muscles
elastic tissue
fibrous tissue
What is the Intima of the arterial wall composed of?
single layer of endothelial tissue
Describe the anatomy of the artery wall
- Thick and firm
- Dilate with systole to a small degree
- Low capacitance
In ASCVD initially, within the endothelial cells there is an inflammatory response with accumulation of what type of cells?
WBCs
Macrophages
In ASCVD, after WBCs and macrophages accumulate what happens next?
- Accumulation of cholesterol and triglycerides into a fatty deposit called and atheroma
- Accumulation of Ca2+
- Mass reduces elasticity of the artery (stiff) and narrow the lumen (hardening)
What is the progression of endothelial dysfunction?
- Initial lesion
- Fatty streak
- Intermediate lesion
- Atheroma
- Fibroatheroma
- Complicated lesion
What is a granuloma?
Accumulation of inflammatory cells 2/2 to an inflammatory process
(seen in Arteritis)
In Takayasu’s Arteritis what main vessel in involved?
Carotid artery (will see thickening of the wall on imaging)
There is one place you can actually see the arteries and veins..where is it?
The fundus of the eye
arteries appear redder sat. = 90-95%
Arteriole function
- Control amount of resistance through vasoconstriction and vasodilation
- Greatest drop in pressure occurs
Distal arterioles have only what 2 layers?
- media (smooth muscle)
- intima
What are the intrinsic mechanisms (autoregulation) for arterioles?
-Metabolic or myogenic controls
Distribute blood flow to individual organs and tissues as needed
What are the extrinsic mechanisms for arterioles?
- Neuronal or hormonal controls
- Maintain MAP
- Redistribute blood during exercise and thermoregulation
What metabolic factors will cause vasodilation of the arterioles?
Dec O2 Inc CO2, H+, K+ Prostaglandins Adenosine Nitric oxide
What neuronal and hormonal factors will cause vasodilation of the arterioles?
- Dec sympathetic tone
- Atrial natriuretic peptide (ANP - maintains fluid level and BP)
What neuronal and hormonal factors cause vasoconstriction of arterioles?
- Inc sympathetic tone
- Angiotensin II
- Antidiuretic hormone
- Epi and NE