Vessels Flashcards
monckberg medial sclerosis
calcification walls muscular arteries
not clinically signif
>50y
Atherosclerosis artery type most commonly affected
elastic
Layer involved atherosclerosi
tunica intima
Vessels most common atherosclerosis
lower abdominal aorta
coronary arteries
popliteal arteries
internal carotid arteries
circle of willis
Metalloproetinases
control collagen turnover - if increased more collagen broken down
causes aortic aneurysm
- atherosclerosis
- HTN (ascending)
Risk AAA rupture by size
4-5cm 1%y
5-6 11%
6+ 25%
Causes dissection
90% htn older people
other younger CT
De Bakey classification
I - all (A)
II - ascending (A)
III - descending (B)
Mortality dissection
Type A most common - 15-35% with tx (70 if haemorrhage)
Type B - 25%
GCA
> 40yo
assoc PMR
Large/ medium
50% ophthalmic
T cell response to wall antigen
Takayasu
like GCA but younger patients
large/ medium
aortic arch involved - pulseless upper limbs
PAN
small medium muscular arteries
kideny most involved
30% assoc hep B
young adults, relapsing and remitting
inc BP, abdo pain, bloody stool, myalgia
Kawasaki
large medium vessels
acute febrile self limiting with viral trigger <4y
coronary artery aneurysm
conjuct oral erythema and blistering
erythema palms and soles
desquamative rash
oedema hand and feet
CREAM
conjunctivitis
Rash
Erythema (hands feet)
Adenopathy
Mucous membranes
Microscopic polyangitis
capilaries, erterioles, venules
90% necrotising glomerulonephritis
haemoptysis, haematuria, palpable purpura
