Environmental Flashcards
cause glutathione depletion
selenium and cysteine deficiency
glucoronidation
phase 2 - excreted un urine
CO poisoning
cherry red
hypoxic at 20-30%
death at 70-80%
LT damage basal ganglia and lenticular nuclei
Lead poisoning
adults peripheral neuropathy
kids absorb more, central
interferes calcium and phosphate metabolism
bone problems
iq, hearing, nerve conduction
colic and anaemia
Lead poisoning blood film
ring sideroblasts
punctate basophilic stippling
microcytic hypochromic anaemia
Mercury poisoning
damages cns and kidneys
inhaled - tremors, gingivitis, altered mental state
minamata disease if in utero exposure
Arsenic poisoning
diarrhoea, skin, heart, nervous system
2-8w post - parasthesia, pain
skin - hyperpigmentation, hyperkaratosis
cancer - skin, lungs, bladder
radon
risk lung cancer
HRT risks
uterine cancer, breast cancer
VTE risk
decreased risk MI and osteopoerosis
COCP risk
cervical Ca risk
decreased risk endometrial and ovarian
risk hepatic adenoma
Cocaine risk
vasospasm
dilated cardiomyopathy
fetal hypoxia
(dopamine agonist)
Heroin risk
endocarditis, APO, amyloidosis, focal glomerulosclerosis
Marasmus
weight 60% normal, visceral protein maintained
hypoplastic BM
cerebral atrophy
Kwashiorkor
protein deficiency greater than calorie
hepatomegaly
increased mitotic index SI
hypoplastic BM
cerebral atrophy
Dermatitis assoc
Adiponectin
from adipocytes
directs FA to muscle for oxidation
decreases glucose production liver
Increases insulin sensitivity
