Venous Thrombosis Flashcards
where can arterial thrombotic events occur?
Coronary
Cerebral
Peripheral
Where can venous thrombotic events occur?
Deep venous thromboses
PE
What causes arterial throbosis?
Atherosclerosis
Platelet rich thrombus
What is the Tx of Arterial thrombosis?
Aspirin
Anti-platelets
Modify RFs
What are venous thrombi rich in?
Fibrin clot
What is virchows triad?
Stasis
Vessel wall
Hypercoagulability
What is the treatment of venous thrombosis?
Heparin
Warfarin
What are the symptoms of DVT?
Hot swollen and tender limb
Pitting odema
What are the symptoms/signs of PE?
Pulmonary infarction Pleuritic chest pain Cardiovascular collapse/death Hypoxia Right heart strain
What are some risk factors for venous thromboembolism (VTE)?
Age Obesity Pregnancy HRT DVT Trauma Malignancy Infection Thrombophilia
What happens to create hypercoaguability?
TF
VWF
factor VIII
What is thrombophilia?
Disorders predisposing to thrombosis
What causes thrombophili?
Increased coagulation
Decreased fibrinolytic activity
Decreased anticoagulant activity
What are some hereditary thrombophilias?
factor V leiden Prothrombin 20210 mutation anti-thrombin deficiency Protein C deficiency Protein S deficiency
When shoudl you screen for hereditary thrombophilia/
Venous thrombosis <45
Recurrent Venous thrombosis
Unusal VT
FH
What is the management of hereditary thrombophilua?
Avoid risk
Short term prophylaxis
Short term anticoagulation
Long term anticoagulation
What is an acquired thrombophilia?
Antiphospholipid syndrome
What are some features of anti-phospholipid syndrome?
Recurrent thromboses
Recurrent fetal loss
Mild thrombocytopenia
What is the pathogenesis of antiphospholipid syndrome?
Abs chance B2glycoprotein1 which activates primary and secondary haemostasis and vessel wall abnormalities
What conditions are associated with anti-phospholipid antibodies?
Autoimmune idsorders Lymphoproliferative disorders Viral infections Drugs Primary
What is the treatment of antiphospholipid syndrome?
Aspirin
Warfarin
