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Hee-matte-ology > Venous Thrombosis > Flashcards

Venous Thrombosis Flashcards

1
Q

where can arterial thrombotic events occur?

A

Coronary
Cerebral
Peripheral

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2
Q

Where can venous thrombotic events occur?

A

Deep venous thromboses

PE

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3
Q

What causes arterial throbosis?

A

Atherosclerosis

Platelet rich thrombus

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4
Q

What is the Tx of Arterial thrombosis?

A

Aspirin
Anti-platelets
Modify RFs

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5
Q

What are venous thrombi rich in?

A

Fibrin clot

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6
Q

What is virchows triad?

A

Stasis
Vessel wall
Hypercoagulability

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7
Q

What is the treatment of venous thrombosis?

A

Heparin

Warfarin

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8
Q

What are the symptoms of DVT?

A

Hot swollen and tender limb

Pitting odema

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9
Q

What are the symptoms/signs of PE?

A 
Pulmonary infarction
Pleuritic chest pain
Cardiovascular collapse/death
Hypoxia
Right heart strain
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10
Q

What are some risk factors for venous thromboembolism (VTE)?

A 
Age
Obesity
Pregnancy
HRT
DVT
Trauma
Malignancy
Infection
Thrombophilia
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11
Q

What happens to create hypercoaguability?

A

TF
VWF
factor VIII

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12
Q

What is thrombophilia?

A

Disorders predisposing to thrombosis

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13
Q

What causes thrombophili?

A

Increased coagulation
Decreased fibrinolytic activity
Decreased anticoagulant activity

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14
Q

What are some hereditary thrombophilias?

A 
factor V leiden
Prothrombin 20210 mutation
anti-thrombin deficiency
Protein C deficiency
Protein S deficiency
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15
Q

When shoudl you screen for hereditary thrombophilia/

A

Venous thrombosis <45
Recurrent Venous thrombosis
Unusal VT
FH

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16
Q

What is the management of hereditary thrombophilua?

A

Avoid risk
Short term prophylaxis
Short term anticoagulation
Long term anticoagulation

17
Q

What is an acquired thrombophilia?

A

Antiphospholipid syndrome

18
Q

What are some features of anti-phospholipid syndrome?

A

Recurrent thromboses
Recurrent fetal loss
Mild thrombocytopenia

19
Q

What is the pathogenesis of antiphospholipid syndrome?

A

Abs chance B2glycoprotein1 which activates primary and secondary haemostasis and vessel wall abnormalities

20
Q

What conditions are associated with anti-phospholipid antibodies?

A 
Autoimmune idsorders
Lymphoproliferative disorders
Viral infections
Drugs
Primary
21
Q

What is the treatment of antiphospholipid syndrome?

A

Aspirin

Warfarin

Hee-matte-ology (17 decks)

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