Anti-platelets drugs Flashcards
What is atherosclerosis?
Damage to endothelium
Recruitment of foamy macrophages in rich cholesterol
Forms plaques rich in cholesterol
What are stable atherosclerotic plaques?
Hyalinised and calcified
Where are stable plaques seen?
Stable angina
Intermittent claudication
When are unstable atherosclerotic plaques seen?
Unstable angina
Myocardial infarction
When are plaques more likely to rupture??
In high pressure environment
What are risk factorsnfor arterial thrombosis?
Hypertension
Smoking
High cholesterol
Diabetes mellitus
What can be done to prevent arterial thrombosis?
Stop smoking Treat hypertension Treat diabetes Lower cholesterol Anti-platelet drugs
How do platelets bind to subendothelial collagen?
Glycoprotein 1b
Von Willebrand factor
How do platelets attach to each other?
GP2b3a and fibrinogen
What granules stimulate and recruit platelets?
Thrombin
Thromboxane A2
ADP
How does aspirin work?
Inhibits cyclo-oxygenase which is necessary to produce thromboxane A2
What are the side effects of aspirin?
Bleeding
Blocks production of prostaglandins
Gi ulceration
Brochospasm
What other antiplatelet drugs exist?
ADP receptor antagonists -Clopidogrel -Prasugrel Phosphodiesterase inhibitor -Dipyridamole GP IIb/IIIa inhibitors -Abciximab
How long before an operation should anti-platelets be stopped?
7 days
