Venous thrombosis Flashcards
what are arterial clots made of
platelet rich - as a result of atherosclerosis
what are venous clots made of
fibrin rich - as part of coagulation cascade
how are arterial clots treated
aspirin / antiplatelets
how are venous clots treated
anticoagulation
virchows triad
stasis
vessel wall damage
hypercoagulability
dvt symptoms
hot swollen tender leg
pitting oedema
PE symptoms
PLEURITC CHEST PAIN hypoxia breathless right heart strain cardiovascular collapse
risk factors for VTE
age obese pregnancy puerperium oestrogen therapy previous VTW trauma or surgery malignancy paralysis infection thrombophilia
what is thrombophilia
familial or acquired disorders of blood which predispose to thrombosis
name hereditary thrombophilias
factro V leidan
Prothrombin 20210 mutation
antithrombin deficiency
protein C and protein S deficeincy
when to consider hereditary thrombophilia screening
venous thrombosis under 45
recurrent vte
unusual VTE
family history or VTE or thrombophilia
how to manage hereditary thrombophilia
Advice on avoiding risk Short term prophylaxis to prevent thrombotic events during periods of known risk Short term anticoagulation to treat thrombotic events Long term anticoagulation if recurrent thrombotic events
name acquired thrombiphilias
antiphospholipid antibody syndrome
stronger risk for VTE than the hereditary thrombophilias
there is activation of both primary and secondary haemostasis
symptoms of syndrome
recurrent thrombosis both arterial and venous
recurrent miscarriage
mild thrombocytopenia
key investigation of antiphospholipid syndrome
reduced prothrombin time
