Antiplatelet

Question 1

what is atherosclerosis

Answer 1

damage to endothelium of artery wall results in recruitment of foamy macrophages and cholesterol deposition

plaques cholesterol rich

Question 2

decribe how a plaque forms an arterial clot

Answer 2

plaque ruptures and platelets recruited - platelet rich clot forms

Question 3

risk factors for arterial thrombosis

Answer 3

hypertension
smoking
high cholesterol
diabetes

Question 4

mechanism of action of aspirin

Answer 4

inhibitis cyclo oxygenase which is necessary to produce thromboxane 2 - platelet agonist)

Question 5

side effects of aspirin

Answer 5

bleeding

blockage of prostaglandins: GI ulceration and bronchospasm

Question 6

mechanism of action of clopidogrel

Answer 6

ADP receptor antagonist

Question 7

mechanism of action of dipyrimaole

Answer 7

phosphodiesterase inhibitors

reduces cAMP production -for platelet activation

Question 8

what is abciximab

Answer 8

GP IIb/IIIa inhibitors - what platelets use to bind to each other - prevents aggrigation

Question 9

how long shoudl antiplatelrts be stopped before surgery

Answer 9

7 days