Structure and function of lymph nodes and spleen

Question 1

where does b cell maturation occur

Answer 1

bone marrow and lymph nodes

Question 2

where does t cell maturation occur

Answer 2

thymus

Question 3

which part of the lymph node is the b cell zone

Answer 3

cortex

Question 4

which part of the lymph node is the t cell zone

Answer 4

paracortex

Question 5

which part of the lymph node has mainly plasma cells

Answer 5

medulla

Question 6

name the centres in the lymph node follicle

Answer 6

mantle
germinal
marginal

Question 7

what is a b cell marker

Answer 7

CD20

Question 8

What is a t cell marker

Answer 8

cd3

Question 9

what is lymphagitis

Answer 9

infection of the lymph channels

Question 10

what things have a predominat b cell response

Answer 10

autoimmune

infections

Question 11

what has a primarily phagocytic response

Answer 11

tumour draining

Question 12

what has a mainly t cell response

Answer 12

viral infections eg drugs

Question 13

how big is a normal spleen

Answer 13

about 12 x 7 x3 cm - not normally palpable

Question 14

what are the different parts of the spleen parenchyma

Answer 14

red pulp

white pulp

Question 15

what is contained in red pup

Answer 15

sinusoids and cords

sinusoids are fenestrated, lined by endothelial cells and supported by reticullin

cords contain macrophages, fibroplasts, WBCs etc

Question 16

what does white pulp form

Answer 16

the periarterioloar lymphoid sheath PALS - antigens reach white pulp via blood - can induces immune response

Question 17

name some symptoms of splenomegaly

Answer 17

draggin sensation in left upper quadrant
discomfort when eating or full quickly
pain if infarction

Question 18

what is hypersplenism

Answer 18

Triad of

1. splenomegaly
2. fall in one or more cellular components of blood
3. correction of cytopenias by splenectomy

Question 19

give haematological causes of splenomegaly

Answer 19

haemolysis
lymphoma/leukaemia
ITP
myeloproliferative disorders

Question 20

name other causes of splenomegaly

Answer 20

infection eg EBV, TB
portal congestion
rheumatoid arthritis
SLE
Niemann Pick disease
Amyloid, tumours

Question 21

other than splenectomy what can cause hyposplenism

Answer 21

coeliac
sickle cell
sarcoidosis

Question 22

what features occur do to reduced red pulp funtion

Answer 22

howell jolly bodies