Structure and function of lymph nodes and spleen Flashcards
where does b cell maturation occur
bone marrow and lymph nodes
where does t cell maturation occur
thymus
which part of the lymph node is the b cell zone
cortex
which part of the lymph node is the t cell zone
paracortex
which part of the lymph node has mainly plasma cells
medulla
name the centres in the lymph node follicle
mantle
germinal
marginal
what is a b cell marker
CD20
What is a t cell marker
cd3
what is lymphagitis
infection of the lymph channels
what things have a predominat b cell response
autoimmune
infections
what has a primarily phagocytic response
tumour draining
what has a mainly t cell response
viral infections eg drugs
how big is a normal spleen
about 12 x 7 x3 cm - not normally palpable
what are the different parts of the spleen parenchyma
red pulp
white pulp
what is contained in red pup
sinusoids and cords
sinusoids are fenestrated, lined by endothelial cells and supported by reticullin
cords contain macrophages, fibroplasts, WBCs etc
what does white pulp form
the periarterioloar lymphoid sheath PALS - antigens reach white pulp via blood - can induces immune response
name some symptoms of splenomegaly
draggin sensation in left upper quadrant
discomfort when eating or full quickly
pain if infarction
what is hypersplenism
Triad of
- splenomegaly
- fall in one or more cellular components of blood
- correction of cytopenias by splenectomy
give haematological causes of splenomegaly
haemolysis
lymphoma/leukaemia
ITP
myeloproliferative disorders
name other causes of splenomegaly
infection eg EBV, TB portal congestion rheumatoid arthritis SLE Niemann Pick disease Amyloid, tumours
other than splenectomy what can cause hyposplenism
coeliac
sickle cell
sarcoidosis
what features occur do to reduced red pulp funtion
howell jolly bodies
