Vasopressin analogues

Question 1

MOA of Terlipressin?

Answer 1

Vasopressin analogue. selectively causes splanchnic and extrarenal vasoconstriction by stimulation of V1 receptors, which are predominantly located in the smooth muscles of the arterial vasculature in the splanchnic region and thereby reduces splanchnic blood flow and portal pressure

Question 2

This drug is used to reduce portal hypertension in hepato-renal syndrome. It acts as a vasoconstrictor predominantly in the splanchnic circulation

Answer 2

Terlipressin

Question 3

This drug is a synthetic vasopressin analogue used in the management of patients with septic shock

Answer 3

Terlipressin