Drugs for dementia

Question 1

MOA: Acetylcholinesterase inhibitor

Answer 1

Donepezil (counteracts the decrease in activity of brain’s cholinergic system as seen in Alzheimer’s and dementia with PD)

Question 2

MOA: NMDA receptor antagonist

Answer 2

Memantine

Question 3

Acetylcholinesterase inhibitors (Donepezil) should be avoided in patients with asthma or COPD due to the risk of (?)

Answer 3

bronchospasm

Question 4

Which drug is licensed for the treatment of moderate to severe Alzheimer’s disease?

Answer 4

Memantine (NMDA receptor antagonist)

Question 5

Contraindications for Donepezil?

Answer 5

Heart block and sick sinus syndrome (rare but serious side effect)

Question 6

Which drug is indicated for patients with mild to moderate Alzheimer’s disease, or dementia with Lewy bodies?

Answer 6

Donepezil (acetylcholinestease inhibitors)