Pharmacology

Question 1

“What the body does to the drug” (ADME)

Answer 1

Pharmacokinetics

Question 2

“What the drug does to the body”

Answer 2

Pharmocodynamics

Question 3

The passage of a drug from its site of administration into the plasma

Answer 3

Absorption

Question 4

The process by which a compound is transferred from the general circulation to other parts of the body and into the tissues

Answer 4

Distribution

Question 5

The process by which a drug is chemically altered in a way that facilitates its action OR enhances its elimination from the body

Answer 5

Metabolism

Question 6

Glucuronidation, acetylation, and sulfation are components of ________ of metabolism

Answer 6

Phase 2 (conjugation)

Question 7

Which phase of metabolism involves Cytochrome P450 enzymes?

Answer 7

Phase 1- oxidation, reduction, hydrolysis

Question 8

Main site of Phase 1 and 2 metabolism?

Answer 8

Liver

Question 9

Common enzymatic inhibitors (slows metabolism, more drug builds up in the system)

Answer 9

Amiodarone
Ciprofloxacin
Erythromycin/Clarithromycin
Metronidazole
Fluconazole
Isoniazid
Grapefruit juice

Question 10

Inducers of metabolism (faster metabolism, less drug in the system)

Answer 10

Carbamazepine
Phenytoin
Rifampicin
Alcohol (chronic)

Question 11

Rifampicin _________ the anticoagulant effect of Warfarin

Answer 11

decreases
(it’s an inducer of metabolism)

Question 12

A harmful reaction experienced following the administration of a drug or a combination of drugs under normal conditions of use and which is suspected to be related to the drug

Answer 12

Adverse drug reaction (ADR)

Question 13

Any undesirable event experienced by a patient whilst taking a drug, regardless of whether or not the drug is suspected to be related to the event

Answer 13

Adverse drug event