Vasodilators

Question 1

What channels do vasodilators affect?

Answer 1

K+ channel agonists

Question 2

In vascular endothelium what activates nitric oxide synthase?

Answer 2

Ca2+-CAM

Question 3

Important isoform we talked about in class of nitric oxide synthesis?

Answer 3

endothelial Nitric oxide synthase

Question 4

Where is NOS?

Answer 4

Vascular endothelium

Question 5

Where does NO diffuse to?

Answer 5

Vascular smooth muscle

Question 6

Where is eNOS found?

Answer 6

Endothelial cells of the vasculature

Question 7

Where is Guanylate Cyclase found?

Answer 7

Vascular smooth muscle

Question 8

Effect of acetylcholine on smooth muscle?

Answer 8

Relaxes smooth muscle

Question 9

What does Nitric oxide bind to in Guanylate Cyclase?

Answer 9

Heme iron prosthetic group

Question 10

Protein kinase G relaxes smooth muscles by inhbiting which Ca2+ channel?

Answer 10

Cav1.2

Question 11

Protein kinase G relaxes smooth muscles by stimulation of what?

Answer 11

Ca2+ activated K+ channels

Question 12

A decreased MLC phosphorylation involves what enzyme?

Answer 12

Myosin phosphatase 1

Question 13

Phospholamban has what effect in reference to protein kinase G?

Answer 13

Enhanced Ca2+ uptake in to ER

Question 14

What breaks down Organic nitrates to nitric oxide?

Answer 14

Aldehyde dehydrogenase

Question 15

What occurs with continuous administration of organic nitrates?

Answer 15

Tolerance

Question 16

How and when do you give organic nitrates?

Answer 16

Give sublingually in treatment of acute attacks of angina

Question 17

Tolerance to glyceryl Trinitrate is associated with who?

Answer 17

Munitions workere

Question 18

Glu 504 is efficient at metabolizing what?

Answer 18

GTN

Question 19

What accounts for the the lack of efficacy of GTN in large % of Asian population?

Answer 19

30-50% of Asians have one Lys 504 allele

Question 20

Lys 504 allele also accounts for what?

Answer 20

Alcohol intolerance

Question 21

Where is prostacyclin produced?

Answer 21

Endothelium

Question 22

3 drugs used to treat pulmonary hypertension?

Answer 22

Prostacyclin
Treprostinil
lloprost

Question 23

How do you administer Prostacyclin?

Answer 23

IV

Question 24

How do you administer Treprostinil?

Answer 24

Oral

IV

Question 25

How do you administer lloprost?

Answer 25

Inhalation

Question 26

What does Hydralazine do?

Answer 26

Dilates arterioles preferentially

Question 27

Mechanism of Hydralazine?

Answer 27

Interferes with release of Ca2+ from the ER

Question 28

BiDil is known for treating what?

Answer 28

Decreases mortality in African Americans with CHF

Question 29

What does Nitroprusside do?

Answer 29

Dilates veins and arterioles

Question 30

What limits duration of treatment with nitroprusside

Answer 30

Metabolized in erythrocytes to NO radical, 4CN-, and cyanmethemoglobin

Question 31

Riociguat has what effect on cGMP?

Answer 31

Increases cGMP concentration in VSM

Question 32

Riociguat is a substrate for what?

Answer 32

P-gp, CYP1A1, 3A

Question 33

Sildenafil is a potent and specific inhibitor of what?

Answer 33

cGMP PDE 5

Question 34

PDE 5 is predominant where?

Answer 34

Corpus cavernosum

Question 35

Benefits of Levitra?

Answer 35

Shorter time to onset than Viagra

More selective for PDE5 than Viagra

Question 36

Benefits of Cialis? big dick marley says hello

Answer 36

More selective for PDE5 than Viagra

Longer duration of action than Viagra or Levitra