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Pharm Exam 3 > Sympatholytic pharmacology > Flashcards

Sympatholytic pharmacology Flashcards

1
Q

What effect would an antagonist alone have on receptor activation?

A

Nothing without an agonist floating around

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2
Q

Side effects of alpha 1 receptor antagonists?

A

Orthostatic hypotension
Inhibition of ejaculation
Nasal stuffiness
Tachycardia

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3
Q

B-Haloalkylamines are what kind of antagonist?

A

Non-selective adrenergic receptor antagonist

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4
Q

Besides alpha receptors what else does B-Haloalkylamines inhibit?

A

Acetylcholine, histamine, and serotonin receptors

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5
Q

B-Haloalkylamines reversible or irreversible?

A

Irreversible

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6
Q

What type of antagonist are Imidazolines?

A

Non-selective alpha receptor antagonist

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7
Q

Imidazolines are competitive reversible or irreversible?

A

Reversible

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8
Q

Vascular effect of Imidazolines?

A

Vasodilator

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9
Q

Danger involving Imidazolines?

A

Reflex tachycardia

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10
Q

What type of antagonist are Quinazolines?

A

Alpha 1 adrenergic receptor antagonists

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11
Q

Where are quinazolines excreted?

A

Bile

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12
Q

Function of Quinazolines?

A

Vasodilator

Relaxation of smooth muscle in enlarged prostate and in bladder base

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13
Q

Blockade of a2 receptors increases what?

A

Sympathetic discharge

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14
Q

Folklore says that inhibition of a2 adrenergic receptors with Yohimbine treats what?

A

Male impotence

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15
Q

Suffix to know if a drug is a beta blocker?

A

OLOL

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16
Q

Most important pharmacological effect of propranolol?

A

Reduced renin release

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17
Q

Why is there a contraindication of propranolol for diabetics?

A

Inhibits compensatory glycogenolysis and glucose release in response to hypoglycemia

18
Q

Difference between Nadolol and propranolol?

A

Less lipophilic than propranolol

19
Q

Significant use of nadolol?

A

Migraines

20
Q

What type of antagonist is Timolol?

A

Non-selective B-adrenergic receptor antagonist

21
Q

Significant use of Timolol?

A

Glaucoma

22
Q

How will Beta-Blockers affect pupil size?

A

It won’t

23
Q

Main feature of Beta antagonist Pindolol?

A

Possesses intrinsic sympathomimetic activity and is a partial agonist

24
Q

Benefit of Pindolol?

A

Less likely to cause bradycardia and lipid abnormalities

25
Q

Significance of Carteolol?

A

Basically the same as Pindolol

26
Q

Difference between the nonselective beta blockers and the selective B1 blockers?

A

The selective B1 blockers are “cardioselective” and cause less bronchoconstriction

27
Q

Which selective B1 blocker is known as 10/10 in quality?

A

Atenolol

28
Q

Half life of Esmolol?

A

9 minutes

29
Q

Since it has such a short half life what is Esmolol best used for clinically?

A

Supra-ventricular tachycardia, atrial fib/flutter, perioperative hypertension

30
Q

3rd generation B1 adrenergic receptor antagonists include?

A

Nebivolol

31
Q

What makes up a mixed adrenergic receptor antagonist?

A

Non-selective B receptor antagonist

alpha 1 receptor antagonist

32
Q

Benefit of mixed adrenergic receptor antagonist?

A

The added Beta antagonist will prevent the reflex tachycardia commonly associated with alpha 1 receptor antagonists

33
Q

Which enantiomer antagonizes B blocking activity for Carvediolol?

A

S enantiomer

34
Q

Withdrawal syndrome from Beta blockers involves whaT?

A

Tachycardia
Hypertension
Increase in sympathetic tone

35
Q

When do you not use beta blockers?

A

Asthma
COPD
Type 4 congestive heart failure

36
Q

What is the catecholamine deplete we talked about in class?

A

Reserpine

37
Q

Function of Reserpine?

A

Block vesicular monoamine transporters

Deplete vesicular pool of NE

38
Q

Slow onset of activation gives what benefit for Reserpine?

A

Won’t activate baroreceptors

39
Q

How long does Reserpine last?

A

Sustained effect (weeks)

40
Q

Reserpine is used to treat what?

A

Hypertension

41
Q

Reserpine led to the discovery of what through its ability to precipitate depression?

A

Discovery of anti-depressants

Pharm Exam 3 (10 decks)

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