Organization of the nervous system

Question 1

Dopamine affects which receptors?

Answer 1

Beta receptors

Question 2

Norepinephrine affects which receptors?

Answer 2

Alpha receptors

Beta 1 receptors

Question 3

Epinephrine affects which receptors?

Answer 3

Nonselective, hits all receptors

Question 4

Which receptor is the cardiovascular control system in the medulla?

Answer 4

Alpha 2

Question 5

Drug that is best alpha 1 receptor agonist?

Answer 5

Phenylephrine

Question 6

Drug that is best B1 receptor agonist?

Answer 6

Isoproterenol

Question 7

Drug that is best B2 receptor agonist?

Answer 7

Isoproterenol

Question 8

Norepinephrine effect on pulse rate?

Answer 8

Decreased

Question 9

Norepinephrine effect on blood pressure?

Answer 9

Increased

Question 10

Norepinephrine effect on peripheral resistance?

Answer 10

Vasoconstriction, increased

Question 11

Epinephrine effect on pulse rate?

Answer 11

Increased

Question 12

Epinephrine effect on blood pressure?

Answer 12

no effect

Question 13

Epinephrine effect on peripheral resistance?

Answer 13

Vasodilation

Question 14

Isoproterenol effect on pulse rate?

Answer 14

Increased

Question 15

Isoproterenol effect on blood pressure?

Answer 15

Decreased slightly

Question 16

Isoproterenol effect on peripheral resistance?

Answer 16

Vasodilation

Question 17

Uses for Epinephrine?

Answer 17

Anaphylaxis

Glaucoma

Question 18

Phenylephrine is a substrate for what?

Answer 18

MAO (Monoamineoxidase)

Not COMT

Question 19

Phenylephrine uses?

Answer 19

Mydriasis without cycloplegia
glaucoma
Pressor
Nasal decongestant

Question 20

Main functional trait of a1 receptor agonist imidazoline?

Answer 20

Basic nature of imidazoline ring causes compounds to exist in ionized form at physiologic pH, not absorbed well so they work locally

Question 21

Where does clonidine bind to receptors?

Answer 21

a2 receptors in the nucleus of the solitary tract in the medulla

Question 22

Uses for clonidine?

Answer 22

Hypertension

Opiate withdrawal

Question 23

How do a2 adrenergic agonists reduce blood pressure?

Answer 23

They reduce sympathetic output from the brain

Question 24

Which a2 receptor agonist has the shortest half life?

Answer 24

Guanabenz

Question 25

Guanfacine is used to treat which behavioral disorder?

Answer 25

ADHD

Question 26

a2 receptor agonist we talked about that works as a prodrug?

Answer 26

Methyldopa

Question 27

Tizanidine is used to treat what?

Answer 27

Muscle spasticity

Question 28

Adverse effects of a2 receptor agonist?

Answer 28

Sedation
Sodium and water retention
Dry mouth
Withdrawal syndrome

Question 29

Main function of isoproterenol?

Answer 29

Bronchodilation

Question 30

Albuterol is what kind of agonist?

Answer 30

Beta 2 receptor agonist

Question 31

Albuterol used to treat what?

Answer 31

Asthma

COPD

Question 32

Problem with using Salmeterol for acute asthma symptoms?

Answer 32

It takes 20 minutes to activate

Question 33

+ enantiomer of Dobutamine affects what receptors?

Answer 33

B1 receptor agonist, a1 antagonist

Question 34

• enantiomer of Dobutamine affects what receptors?

Answer 34

a1 agonist, potency of B receptors reduced 10X

Question 35

Use for Dobutamine?

Answer 35

Acute heart failure/shock

Question 36

Amphetamines have what effect on sympathetics?

Answer 36

Reverse the NE transporter

Question 37

Coccaine has what effect on sympathetics?

Answer 37

Blocks the NE transporter

Question 38

Clinical uses for Amphetamines?

Answer 38

ADHD
Narcolepsy
Anorexiant
Nasal Decongestant

Question 39

How does D(-)Ephedrine work?

Answer 39

Direct agonist activity at adrenergic receptors

Question 40

How does L(+)Pseudoephedrine work?

Answer 40

Reduces agonist activity-major mechanism is via reversal of the transporter