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Pharm Exam 3 > Intro to autonomic pharm > Flashcards

Intro to autonomic pharm Flashcards

1
Q

What diseases/problems can cause autonomic nervous system disorders? (6)

A 
Poisoning
Dementia with Lewy bodies
Diabetes Mellitus
Multiple Sclerosis
Alcoholism 
Drugs
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2
Q

Side effects of clozapine? (3)

A

Dry mouth
Slowed heart beat
Constipation

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3
Q

Two divisions of the autonomic system?

A

Sympathetic (Fight/Flight)

Parasympathetic (Rest and Digest)

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4
Q

Adrenergic neurotransmitters fall into which category of ANS?

A

Sympathetic

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5
Q

What are the two adrenergic neurotransmitters?

A

Epinephrine and Norepinephrine

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6
Q

Cholinergic neurotransmitters fall into which category of the ANS?

A

Parasympathetic

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7
Q

What is the Cholinergic neurotransmitter?

A

Acetylcholine

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8
Q

What are the two exogenous cholinergic categories?

A

Muscarine

Nicotine

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9
Q

What is dopamine a precursor of?

A

Norepinephrine

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10
Q

How do Ritalin and Adderall activate SANS indirectly?

A

Releasing NE

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11
Q

How do drugs influence the ANS?

A

Mimic or block the effects of two primary neurotransmitters Acetylcholine, and Norepinephrine/Epinephrine

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12
Q

Drugs that mimic acetylcholine are referred to as what?

A

Cholinergic = muscarinic agonists = parasympathomimetic

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13
Q

Drugs that block acetylcholine referred to as what?

A

Anticholinergic = muscarinic antagonist = parasympatholytic

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14
Q

Drugs that mimic norepinephrine referred to as what?

A

Adrenergic = Adrenergic agonist = sympathomimetic

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15
Q

Drugs that block norepinephrine referred to as what?

A

Antiadrenergic = adrenergic antagonist = sympatholytic

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16
Q

Where are nicotinic receptors located?

A

Ganglions
Skeletal muscle
Neuronal CNS

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17
Q

Nicotinic receptors are made out of what?

A

Ion channels made out of 5 subunits

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18
Q

Which muscarinic receptor is ubiquitous?

A

M3

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19
Q

Where is muscarinic receptor 2 located? (4)

A

Heart
Bladder
Hippocampus
Cerebral Cortex

20
Q

What are two characteristics of muscarinic receptors?

A

7 transmembrane domain

G-protein coupled receptors

21
Q

What groups on Adrenergic receptors are there? (3)

A

a1
a2
B

22
Q

Adrenergic receptors a1 are coupled how?

A

Gq coupled

23
Q

Adrenergic receptors B are coupled how?

A

Gs coupled

24
Q

Which receptor causes contraction of the ciliary muscle?

A

M3

25
Q

What does B2 adrenergic receptor cause in the ciliary epithelium?

A

Increase secretion of aqueous humor

26
Q

Circular muscles of the eye are under the care of what receptor?

A

M3

27
Q

Radial muscles of the eye are taken care of by what receptor?

A

a1

28
Q

Equation for pressure?

A

Pressure = Flow (Q) x Resistance (R)

29
Q

Equation for flow?

A

Stroke volume (SV) x Heart Rate (HR)

30
Q

What does Nitric Oxide do?

A

Muscle relaxation

31
Q

What happens in pathologies where the vascular endothelium is disrupted?

A

M3 receptor vasocontriction

32
Q

Which ANS responses are in the heart?

A

M2 and B1

33
Q

Which receptors are found in apocrine sweat glands?

A

a1

34
Q

Eccrine sweat glands have what kind of receptor?

A

M3

35
Q

Salivary glands sympathetic and parasympathetic response?

A

Sym: Increase secretion
Para: Increase secretion

36
Q

Receptors involved in salivary glands?

A

a1

M3

37
Q

In smooth muscle wall what is the sympathetic and parasympathetic response?

A

Sym: Relaxation
Para: Contraction

38
Q

In smooth muscle wall what receptors are involved?

A

a2, B2

M3

39
Q

In smooth muscle sphincter what is function of sympathetic and parasympathetic response?

A

Sym: Contraction
Para: Relaxation

40
Q

In smooth muscle sphincters what receptors are involved?

A

a1

M2

41
Q

smooth muscle Sympathetic and parasympathetic response for secretion?

A

Sym: Inhibit secretion
Para: Increase secretion

42
Q

Which receptors are involved with smooth muscle secretion?

A

a2

M1, M3

43
Q

Liver Metabolic functions carried out by adrenergic? (2)

A

Glycogenolysis

Gluconeogenesis

44
Q

Fat cell function by adrenergic?

A

Lipolysis

45
Q

Kidney function by adrenergic?

A

Increase renin secretion

46
Q

Pancreas function by adrenergic?

A

Decrease insulin release

Pharm Exam 3 (10 decks)

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