Vasodilators

Question 0

Indications for specialist vasodilators

Answer 0

ACS, severe hypertension, anaesthesia, critical care, unstable, monitoring and IV route

Question 1

Specialist vasodilators

Answer 1

PDEI, Mg, alpha 2 agonists, nitroptusside, dobutamine, hydralazine

Question 3

Vasoconstrictors

Answer 3

Adrenaline, noradrenaline, dopamine. Synthetic - phenylephrine, non-catecholamine - vasopressin, angiotensin. Vasopressin, angiotensin ( non-catecholamine)

Question 4

Mechanism of action of adrenaline

Answer 4

alpha and beta agonist

Question 5

How does it affect beta and alpha receptors

Answer 5

B1 increased HR, increased CO, SV. B2 bronchodilation. Vasoconstriciton due to alpha receptors.

Question 6

When is NA used?

Answer 6

ITU to rescue BP, in spectic shock. Potent effect on alpha1 to vasoconstrict, significant side effect profile. Used in cardiac arrest and anaesthesia aswell

Question 7

Mechanism of action of NA?

Answer 7

Increase calcium

Question 8

MOA of GTN, nitrates

Answer 8

Produces NO which increases cGMP and reduces calcium. Causes venous dilatation - decreased venous return (preload), decreased myocardial oxygen demand, increased coronary blood flow so better pump function