GI

Question 0

Loperamide

Answer 0

Opioid receptor agonist, increases transit time

Question 1

Racecadotril

Answer 1

Inhibits enkephalinase so prolongs action of enkephalins which act at opioid receptors. Reduces hyper secretion without affecting transit time

Question 2

Antacids ie Gaviscon

Answer 2

Neutralise acid

Question 3

Alginates ie sodium bicarbonate, magnesium and aluminium salts, simeticone, sodium alginate

Answer 3

Increase viscosity of stomach contents reducing symptoms of reflux

Question 4

Sucralfate, misoprostol

Answer 4

Promote mucosal defense (for reflux). Misoprostol is a prostaglandin analogue

Question 5

Metoclopramide, domperidone

Answer 5

Gastric stimulants

Question 6

H2 receptor antagonists (cimetidine), proton pump inhibitors (omeprazole)

Answer 6

Reduce acid production

Question 7

Function of COX 1

Answer 7

Prostaglandin production, protection of gastric mucosa and platelet function

Question 8

Function of COX 2

Answer 8

Pain, inflammation, fever via prostaglandin release