Vasculitides Flashcards
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Name the 2 large vessel vasculitides. Which one is seen in women <30, and which one in patients around 70?
Takayasu arteritis and giant cell arteritis / temporal arteritis; Takayasu has the younger age of onset
Which vasculitis can be associated with “aortic arch syndrome,” pulseless disease, and vasa vasorum inflammation that resembles syphilis aortitis?
Takayasu arteritis
What vasculitis is associated with polymyalgia rhuematica and HLA-DR4, as well as activated CD4 T cells, MMPs, and the luekocyte adhesion molecule ICAM-1? It has a dramatic response to corticosteroids.
Giant cell / temporal / granulomatous arteritis
What medium vessel, acute, necrotizing vasculitis is often seen as nodules in the arteries of the kidneys?
Polyarteritis nodosa
What medium vessel, childhood vasculitis, a.k.a mucocutaneous lymph node syndrome, targets the coronary arteries?
Kawasaki disease
Microscopic angiitis, cutaneous leukocytoclastic vasculitis, cutaneous necrotizing venulitis, and microscopic polyarteritis/polyangiitis all belong to what category of blood vessel diseases?
Hypersensitivity angiitis (response to exogenous substances)
What disease presents with palpable purpura on the lower extremities and fibrinoid necrosis of sperficial venules with acute inflammation?
Cutaneous vasculitis (the main kind of hypersensitivity angiitis)
What small-vessel vasculitides are associated with p-ANCA and c-ANCA?
p-ANCA: microscopic polyangiitis and Churg-Strauss
c-ANCA: Wegener’s
What proteins are targeted by p-ANCA and c-ANCA?
p-ANCA: MPO (myeloperoxidase)
c-ANCA: proteinase 3
What is the difference between microscopic polyarteritis (a.k.a. systemic hypersensitivity angiitis) vs. polyarteritis nodosa?
Microscopic polyarteritis is restricted to the smallest arteries and arterioles, but otherwise they have many of the same features and affect similar organs
Systemic necrotizing vasculitis of unknown etiology, characterized by repetitive sinusitis, mucosal ulcers, lung infiltrates, and renal disease?
Wegener’s (granulomatosis with polyangiitis)
Systemic vasculitis affecting the arteries and veins of young patients who have asthma?
Allergic granulomatosis and angiitis (Churg-Strauss / eosinophilic granulomatosis with polyangiitis)
Occlusive, inflammatory, peripheral vascular disease of smokers associated with HLA-A9 and HLA-B5?
Thromboangiitis obliterans (Buerger disease)
Systemic vasculitis that causes destruction of both large and small vessels and involves the mucous membranes to form genital, oral, and ocular ulcers? Can spread to the CNS, GI tract, and heart.
Behcet disease
