Amyloidoses

Question 1

What kind of amyloid is associated with chronic infections and long-term production of the acute phase reactant SAA (serum amyloid protein)?

Answer 1

AA amyloid

Question 2

The main clinical feature of AA amyloidosis / reactive systemic amyloidosis?

Answer 2

Progressive proteinuria

Question 3

What kind of amyloid is associated with monoclonal B-cell dyscrasias leading to monoclonal κ or λ light chains?

Answer 3

AL amyloid

Question 4

Dialysis-related amyloidosis is associated with what kind of amyloid, typically causing arthralgia, joint swelling, and carpal tunnel?

Answer 4

β2-microglobulin

Question 5

What kind of amyloidosis is associated with increasing age in males, and presents with restrictive cardiomyopathy and carpal tunnel?

Answer 5

Senile transthyretin amyloidosis / ATTR

Question 6

Term for the amyloid fibril protein seen in insulinomas and in the islet of Langerhans in type 2 diabetes.

Answer 6

Amylin / islet amyloid polypeptide

Question 7

Amyloid type seen in Alzheimer’s?

Answer 7

Aβ

Question 8

Amyloid type seen in spongiform encephalpathies?

Answer 8

PrPSc (normal form is PrPC)

Question 9

Amyloid type seen in autosomal dominant familial amyloidoses that manifest as peripheral neuropathies?

Answer 9

ATTR / transthyretin amyloid