Autoimmune Diseases Flashcards
Inflammatory, systemic, immune complex (type III, IgG + C3) hypersensitivity disease that can involve almost any organ, but especially joints, skin, and kidneys.
SLE (systemic lupus erythematosus)
What disease is associated with anti-dsDNA and anti-Sm? Dysregulation of what cells lead to their production?
SLE (systemic lupus erythematosus); autoreactive CD4 T cells
What disease is associated with nonbacterial Libman-Sacks endocarditis, antiphospholipid antibodies, and “onion skin” vasculitis of the splenic pencillary arteries?
SLE (systemic lupus erythematosus)
T cell mediated keratoconjunctivitis sicca and xerostomia without underlying disease? There is an 40x increased risk of what cancer?
Sjogren’s; lymphoma
Anti-Ro (SS-A) and anti-La (SS-B) target DNA and nonhistone proteins, and are associated with what disease, the second most common connective tissue disorder after SLE?
Sjogren’s
Progressive systemic sclerosis characterized by vasculopathy and collagen deposition or fibrosis in the skin and internal organs, especially the lungs, heart, and kidneys.
Scleroderma
Scl-70 autoantibody and CREST syndrome are associated with what disease? What does CREST stand for?
Scleroderma; Calcinosis, Raynaud, Esophageal hypomotility, Sclerodactyly, and Telangiectasias
Mixed connective tissue disease is characterized by anti-RNP and combines features of what 3 skin diseases?
SLE, scleroderma, and dermatomyositis
Lupus-like disease associated with procainamide (for arrhythmias), hydralazine (for hypertension) and isoniazid (for tuberculosis) usage, which can test positive for ANA, Rh, syphilis, and Coombs?
Drug-induced lupus
Lupus-like disease with red, depigmented, telangiectatic plaques on the face and scalp but
no anti-dsDNA or anti-Sm, and no immune complexes in uninvolved skin?
Chronic discoid lupus
Lupus-like disease that is aggravated by sunlight and associated with trunk lesions, SS-A/Anti-Ro, and HLA-DR3?
Subacute cutaneous lupus
