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CSI- Winter > Vascular Thromboembolic Disease > Flashcards

Vascular Thromboembolic Disease Flashcards

1
Q

Hemostasis

A

the physiologic process by which bleeding stops

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2
Q

Thrombosis

A

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3
Q

Thrombus

A

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4
Q

Embolization

A

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5
Q

Emboli

A

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6
Q

Key Pathologic Consequence of clot

A

REDUCTION IN or CESSATION OF BLOOD FLOW

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7
Q

Underlying Inciting Event in several Clinical Diseases

A

TIA/CVA, MI, DVT, PE, etc.

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8
Q

Substances that can embolize

A 
Air
Amniotic Fluid
Foreign Bodies
Parasitic Eggs
Septic Emboli
Tumor Cell
MOST COMMON: Thrombus
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9
Q

Location of Thromboembolism

A

can occur anywhere in Cardiovascular System

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10
Q

Purpose of Hemostatic System

A

Prevent blood loss due to vascular Injury

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11
Q

Thrombus: A leading cause of morbidity and mortality

Epidemiology

A

US: cause of death in ~1 million individuals per year

Annual Incidence: ~1 case/1000 individuals

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12
Q

Components of hemostatic system

A

Formed Elements: Cells (Platelets, Monocytes, RBCs) &
Plasma Proteins (Clotting Factors, Fibrinolytic Factors, Inhibitors)
Vessel Wall: Epithelium, vonWillibrand Factor (vWF), Collagen, Tissue Factor

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13
Q

Hemostasis- Vascular Injury

A

will expose VW factor, collagen matrix, etc. and when this is exposed that’s when coagulation occurs

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14
Q

Primary Hemostasis

A

formation of platelet plug

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15
Q

Secondary Hemostasis

A

Clotting Cascade: Activate Fibrin (form meshwork that binds everything together)

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16
Q

Hemostasis- Fibrinolysis and Regulation

A

once clot is formed, further clot formation is prevented and clot starts to breakdown

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17
Q

Arteries

A

Higher Pressure
More smooth muscle
Atherosclerosis

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18
Q

Veins

A

More Distensible
Capacitance Vessels
Valves
Virchow’s Triad

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19
Q

Arterial Thromboembolism may cause

A 
Arterial Occlusive Disease
Myocardial Infarction
Ischemic Cerebrovascular Accident
Mesenteric Ischemia
Vasculitides
20
Q

Venous Thromboembolism (VTE) may cause

A 
PE
DVT
Superior Vena Cava Obstruction
Chronic ThromboEmbolic Pulmonary HTN (CTEPH)
Dural Sinus Thrombosis
Portal Vein Thrombosis
Vasculitis-Bechet’s, Granulomatosis with polyangiitis
Mesenteric Vein Occlusion
21
Q

Pulmonary venous thromboembolism (AKA PE)

A

3rd leading cause of death among hospital pts

Often not recognized ante mortem

22
Q

Thrombus description

A
  • Most common etiology of emboli
  • Most Common Site of Origin is Deep Veins of the Lower extremities
  • Found in 50-70% of pts with symptomatic PE
  • Can Form AnywhereThrombus
23
Q

Diagnosis of VTE (venous thrombolytic embolism)

A
  • NOTORIOUSLY DIFICULT DIAGNOSIS
  • Findings depend of size of embolus and preexisting cardiopulmonary disease
  • Common signs and symptoms are not specific
24
Q

Signs & Symptoms of VTE

A

*Dyspnea
*Pain on inspiration
*Tachypnea
Cough
Hemoptysis
Leg Pain
Tachycardia
Palpitations
Crackles
Homan’s Sign- Dorsiflex foot and have calf tenderness (may be indication of DVT)

25
DIFFERENTIAL DIAGNOSIS for VTE
``` Pneumonia Lung Cancer MI COPD Asthma Traumatic Injury Muscle Strain Costochondritis Inhalation Injury Aortic Aneurysm Congestive Heart Failure ```
26
Virchow’s Triad- 3 things that promote coagulability
Stasis, Hypercoagulability, Endothelial injury
27
Description of Stasis (part of Virchow's triad)
``` Stasis Prolonged immobility post orthopedic surgery, Low Cardiac Output Pregnancy Post CVA Travel (Air, Car) ```
28
Description of Hypercoagulability (part of Virchow's triad)
Hypercoagulability Medications: Oral Contraception, Hormone Replacement Malignancy Genetic: Factor V Leiden, Protein C/S/antithrombin III deficiency/dysfunction, prothrombin gene mutation, hyperhomcysteinemia, antiphospolipid antibodies
29
Description of Endothelial Injury (part of Virchow's triad)
Traumatic Injury Recent Surgery Previous Thrombosis
30
EKG findings of VTE
- Abnormal in about 70% of pts with PE - Most Common Finding: Sinus Tachycardia & Nonspecific SR and T wave changes - Right Heart Strain: RBBB, Right Axis Deviation, S1Q3T3 - Prominent S wave (lead 1), Prominent Q wave (lead 3) and Inverted T wave (lead 3) -->this may also indicate PE
31
Arterial Blood Gas findings of VTE
- Usually Respiratory Alkalosis - Abnormal pO2 and Alveolar-arterial O2 gradient - NOT DIAGNOSTIC - ->*Profound Hypoxia with Normal Chest X-ray THINK PE*
32
D-dimer
* *Indicative of general clot formation (not specific)** - Fibrin Degradation product - Can be elevated in trauma, always elevated with inflammation - Positive D-dimer DOES NOT INDICATE a PE - Sensitivity 95-97%, Specificity 45% - NO diagnostic threshold established for positive result - BEST INFORMATION WHEN NEGATIVE (indicates NO clot has formed) - Negative
33
Other Lab findings of VTE
- Serum Troponins, BNP typically elevated in PE - Indicative of R heart strain/R heart failure - Not Useful in diagnosis, correlate with adverse outcomes
34
Findings of Chest Xray with VTE
- Useful to rule out other etiologies | - Most Frequent findings: Atelectasis, Parenchymal Infiltrates, Pleural Effusion
35
Uncommon Findings of Chest Xray with VTE
Westermark Sign: prominent central pulmonary artery with local oligemia; Absence of vascular markings distal to engorged central pulmonary vein Hampton’s Hump: pleural based areas of increased opacity representing intraparenchymal hemorrhage (may represent pulmonary infarct as well) LOOK UP PICTURES
36
Gold standard for diagnosing VTE
**CT angiography** (WITH CONTRAST) Very sensitive for large central pulmonary arteries and veins; may see saddle embolus indicated by lack of contrast (filling defect)
37
With VTE, primary and secondary findings of CT angiography are
- Requires IV contrast dye * Primary finding suggestive of PE: Intravascular filling defect, Very sensitive for central vascular filling defects - ~80% sensitive, 96% specific - 15-20% false negative rate (high) *Secondary Findings suggestive of PE: Abrupt arterial cutoff, asymmetrical blood flow, prolonged or slowed filling
38
Normal CT chest requires
initiation of empiric therapy (high pretest probability) or further testing (V/Q scan, etc.)
39
Ventilation Perfusion (V/Q) scan
- Perfusion assessed by injection of radiolabeled albumin injected into venous circulation - Ventilation assessed by records distribution of inhaled radiolabeled gas - The two mages are compared, looking for defects
40
Ventilation Perfusion (V/Q) scan and probability of VTE
- Criteria for assessment are complex, confusing and not standardized - Reported in terms of probability: low, intermediate, and high - PIOPED1; If low, 14% probability of PE. Combined with low pretest probability , lowers risk to 4% - If indeterminate, low or intermediate probability, further testing required (if pretest is low, further testing is required) -Lower extremity doppler may be used to see if there is a blood clot
41
Venous Ultrasonography: positive and negative tests are indicated by ________
- Positive Test: Incompressibility of common femoral or popliteal veins - In a patient with appropriate symptoms (unilateral swelling, erythema of one limb vs. another) --> Positive predictive value 97% (more likely, probably present) - Negative Test: Full compressiblity at both vessels - Negative Predictive value 98% (less likely, probably no there) - Less accurate in distal thrombi, recurrent thrombi, and asymptomatic patients
42
Integrated Approach to PE Diagnosis: Wells Criteria
Wells Criteria: scoring systems to assess PE Risk 1. Clinical Signs and symptoms of DVT: Unilateral edema, and pain with palpation *3 pts* 2. Alternative Diagnosis Less likely than PE (if you’re not suspecting another diagnosis like muscle cramping, traumatic injury, etc) *3 pts* 3. Pulse >100bpm *1.5 pts* 4. Immobilization >3days in past 4 wks *1 pt* 5. Previous DVT/PE *1 pt* 6. Hemoptysis *1 pt* 7. Cancer (With Tx w/in past 6 mo. or Palliation) *1 pt* Total >4pts: Imaging warranted Total
43
People who are HIGH RISK for PE/DVT | DVT/PE ARE preventable
Surgical patients, Major orthopedic procedure/arthroplasty, Abdominal/pelvic cancer undergoing surgery, recent spinal cord injury or major trauma w/in previous 90days, >3 intermediate criteria
44
People who are INTERMEDIATE RISK for PE/DVT | DVT/PE ARE preventable
Ambulation 30, OCP/HRT use, Immobilization >72hrs, Hypercoagulable state, nephrotic syndrome, burns, cellulitis, varicose veins, paresis, Systolic Heart Failure, COPD exacerbation
45
People who are LOW RISK for PE/DVT | DVT/PE ARE preventable
Minor procedures, age
46
Interventions for DVT/PE
Sequential Compression Devices | Medication: Heparin, Lovenox
47
Treatment for Pulmonary VTE
Heparin or Catheter directed tPA

CSI- Winter (44 decks)

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