Vascular System

Question 1

provides the interface between circulating blood and the body tissues.

Answer 1

Vascular intima

Question 2

Innermost Vascular Lining

Answer 2

Endothelial cells (endothelium)

Question 3

Supporting the Endothelial Cells

Answer 3

Internal elastic lamina composed of elastin and collagen

Question 4

Subendothelial Connective Tissue

Answer 4

Collagen and fibroblasts in veins
Collagen, fibroblasts, and smooth muscle cells in arteries

Question 5

ECs play essential roles in

Answer 5

Immune response
Vascular permeability
Proliferation
Hemostasis

Question 6

form a smooth, unbroken surface that eases the fluid passage of blood.

Answer 6

ECs

Question 7

In all blood vessels, __________ occupy the connective tissue layer and produce collagen.

Answer 7

fibroblasts

Question 8

Normally the intact vascular endothelium prevents thrombosis by

Answer 8

inhibiting platelet aggregation,
preventing coagulation activation and propagation, and
enhancing fibrinolysis.

Question 9

Anticoagulant Properties of Intact Vascular Endothelium:

Present a smooth, contiguous surface

Answer 9

Vascular endothelium is composed of rhomboid cells

Question 10

Anticoagulant Properties of Intact Vascular Endothelium:

The eicosanoid platelet inhibitor

Answer 10

ECs secrete prostacyclin

Question 11

Anticoagulant Properties of Intact Vascular Endothelium:

A vascular “relaxing” factor

Answer 11

ECs secrete nitric oxide

Question 12

Anticoagulant Properties of Intact Vascular Endothelium:

An anticoagulant that regulates thrombin generation

Answer 12

ECs secrete the glycosaminoglycan heparin sulfate

Question 13

Anticoagulant Properties of Intact Vascular Endothelium:

A regulator of the extrinsic pathway of coagulation

Answer 13

ECs secrete TFPI

Question 14

Anticoagulant Properties of Intact Vascular Endothelium:

An integral component of the protein C control system

Answer 14

ECs express the protein C receptor EPCR (endothelial protein C receptor)

Question 15

Anticoagulant Properties of Intact Vascular Endothelium:

A protein C coagulation control system activator

Answer 15

ECs express cell membrane thrombomodulin

Question 16

Anticoagulant Properties of Intact Vascular Endothelium:

Activates fibrinolysis

Answer 16

Tissue plasminogen activator (TPA)

Question 17

A platelet inhibitor and a vasodilator, is synthesized through the eicosanoid pathway and prevents unnecessary or undesirable platelet activation in intact cells

Answer 17

Prostacyclin

Question 18

Nitric oxide is synthesized in

Answer 18

ECs
Vascular smooth muscle cells
Neutrophils
Macrophages

Question 19

Induces smooth muscle relaxation and subsequent vasodilation, inhibits platelet activation, and promotes angiogenesis and healthy arterioles

Answer 19

Nitric oxide

Question 20

An important EC - produced anticoagulant which controls activation of the tissues factor pathway, also called the extrinsic coagulation pathway

Answer 20

TFPI