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Hematology 2 > P2: Laboratory > Flashcards

P2: Laboratory Flashcards

1
Q

Sample of clotting time (Lee and white method)

A

Venous blood

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2
Q

In clotting time (Lee and white method) the _______ are the best for there is less contamination of the plasma with tissue fluids when blood is drawn from a vein through venipuncture.

A

Test tube methods

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3
Q

Sources of error in clotting time (Lee and white method)

A
  1. Dirty test tube
  2. Tissue juices mixed with blood
  3. Air bubbles in the blood due to faulty venipuncture
  4. Excessive agitation of blood
  5. Temperature below 35C and above 45C retards coagulation
  6. Diameter of test tubes, the smaller the diameter the more rapid the clot formation
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4
Q

Normal value of clotting time (Lee and white method)

A

5 - 15 mins

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5
Q

In clotting time (Lee and white method), is clothing time is more than 15 mins, it indicates a

A

Deficiency in blood coagulation components

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6
Q

This is a another method of clothing time which uses plain capillary tubes.

A

CLOOTING TIME (CAPILLARY TUBE METHOD BY SABRAZE’S)

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7
Q

What is the end product of CLOTTING TIME (CAPILLARY TUBE METHOD BY SABRAZE’S)

A

Formation of fibrin

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8
Q

Normal capillary clotting time of CLOTTING TIME (CAPILLARY TUBE METHOD BY SABRAZE’S)

A

3-7 minutes

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9
Q

In CLOTTING TIME (CAPILLARY TUBE METHOD BY SABRAZE’S), the puncture depth is

A

3mm

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10
Q

This method is the simplest among all the methods in clotting time

A

Clotting time (Slide or Drop Method)

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11
Q

This method uses clean slide

A

Slide or Drop Method

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12
Q

Normal capillary clotting time for Slide or Drop Method

A

2-4 minutes

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13
Q

In APTT, what is the role of the calcium

A

The calcium in whole blood is bound by the sodium citrate anticoagulant to prevent anticoagulation

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14
Q

In APTT, after centrifugation, the plasma contains

A

The plasma contains all intrinsic coagulation factors except calcium and platelets

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15
Q

What is the activated partial thromboplastin time

A

The time required for the plasma to clot

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16
Q

Normal clotting time for APTT

A

23-40 seconds

17
Q

In APTT, what is the concentration for the substitute for platelets

A

Calcium chloride, 0.025 M

18
Q

Is the most frequently performed tests for coagulation that evaluates the function of the extrinsic and common pathways of hemostasis

A

Prothrombin Time (PT)

19
Q

PT is used not only as a coagulation screening test, but also

A

To monitor oral anticoagulant therapy

20
Q

PT is especially effective for

A

Monitoring patients receiving coumarin

21
Q

PT is also dependent upon factors such as

A

I, II, V, VII, and X

22
Q

It is used means for measuring the effect of anticoagulant

A

Prothrombin Time (PT)

23
Q

Principle of PT

A

The PT test is performed by adding tissue extract (Factors III = tissue factors) and calcium to the plasma. This initiates the activation of factor VII. Activated factor VII in turn, activated thrombin will then convert fibrinogen into fibrin

24
Q

Normal value in PT

A

11-13 seconds

25
Q

Prothrombin index:

A

PT of control
——————- x 100
PT of test

26
Q

Prothrombin ratio

A

PT of test
——————
PT of control

27
Q

Principle of Fibrinogen Degradation Products (FDP)
Thrombo-Wellcoltest Procedure

A

Whole blood is added to Thrombo (to ensure complete clotting) and soya beans enzyme inhibitors (to prevent breakdown of fibrin). After complete clotting, the patient’s serum is diluted and mixed with latex particles coated with anti-FDP (fibrinogen fragment D & E). If fibrinogen degradation products are present, agglutination of the latex particles will occur.

28
Q

In FDP, if the patient is receiving heparin

A

Reptilase- should be added to the patient blood in the sample collection tube in order to complete clotting occur

29
Q

Buffer used in FDP

A

Glycine saline buffer

Hematology 2 (18 decks)

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