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Hematology 2 > Platelet Ultrasctructure > Flashcards

Platelet Ultrasctructure Flashcards

1
Q

Platelet is anatomically divided into four areas:

A
  1. Peripheral Zone
  2. Sol Gel Zone
  3. Organelle Zone
  4. Membranous System
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2
Q

Under the Peripheral Zone

A

a. Glycocalyx
b. Plasma Membrane

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3
Q

Under the Sol Gel Zone

A

a. Microtubules
b. Microfilaments

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4
Q

Under the Organelle Zone

A

a. Mitochondria
b. a-granules
c. Dense granules
d. Lysosomes

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5
Q

Under the Membranous System

A

a. Dense tubular system
b. Surface connecting canalicular system

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6
Q

Outer surface, fuzzy containing primarily composed of glycoproteins

A

Glycocalyx

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7
Q

Bilayer of phospholipids

A

Platelet Membranes

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8
Q

Predominant lipids in Platelet Membrane:

A

a. Phospholipids
b. Cholesterol

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9
Q

A predominant lipid that forms the basic structure

A

Phospholipids

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10
Q

A predominant lipid that distributes asymmetrically throughout the phospholipids

A

Cholesterol

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11
Q

What are the Neutral Phospholipids (Predominant in the plasma layer)

A
  1. Phosphatidyl choline
    B. Sphingomyelin
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12
Q

Anionic or polar phospholipids (Predominates the cytoplasmic layer)

A
  1. Phosphatidylinositol
  2. Phosphatidylethanolamine
  3. Phosphatidylserine
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13
Q

Supplies arachidonic acid

A

Phosphatidylinositol

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14
Q

Flips to the external surface and is responsible in the assembly of the coagulation factor complexes in the surface.

A

Phosphatidylserine

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15
Q

Stabilizes the membrane, maintains fluidity, and helps control the transmembranous passage of materials through the selectively permeable plasma membrane.

A

Cholesterol

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16
Q

Maintains the platelet’s discoid shape

A

Microtubules

17
Q

Microfilaments is composed of

A

Actin and Myosin

18
Q

Intermediate filaments is a ropelike polymers of

A

desmin and vimentin

19
Q

Connects with the actin and the tubules, maintaining platelet shape

A

Intermediate Filament

20
Q

Stains medium-gray in osmium-dye transmission electron microscopy preparations.

A

Alpha Granules

21
Q

Alpha granules fuse with ______ in activated platelets

A

Surface-Connected Canalicular System

22
Q

Appears later than alpha granules

A

Dense granules

23
Q

Stain black (opaque) when treated with osmium in transmission electron microscopy

A

Dense Granules

24
Q

Contents of Dense Granules

A

CAAS

  1. Calcium and Magnesium
  2. ADP
  3. ATP
  4. Serotonin
25
Q

Are condensed remnant of the rough ER

A

Dense Tubular System (DTS)

26
Q

“Control center” for platelet activation

A

Dense Tubular System (DTS)

27
Q

Is the route of endocytosis and for secretion of alpha granule contents upon platelet activation

A

Surface Connecting Canalicular System (SCCS)

Hematology 2 (18 decks)

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