Vascular Disorders

Question 1

Hereditary vascular disorders

Answer 1

• Hereditary hemorrhagic Telangiectasia (Rendy-Osler-Weber Syndrome)
• Hemangioma-Thrombocytopenia Syndrome (Kasabach-Meritt Syndrome)
• Ehlers-Danlos Syndrome and Other Genetic Disorders

Question 2

Acquired Vascular Disorders

Answer 2

• Allergic Purpura (Henoch-Schönlein Purpura)
• Paraproteinemia and Amyloidosis
• Senile Purpura
• Drug – Induced Vascular Purpuras
• Scurvy

Question 3

Characterized by thin-walled blood vessels with discontinuous endothelium, inadequate smooth muscle, and inadequate / missing elastin in the surrounding stoma

Answer 3

Hereditary hemorrhagic Telangiectasia (Rendy-Osler-Weber Syndrome)

Question 4

Universal finding of Hereditary hemorrhagic Telangiectasia (Rendy-Osler-
Weber Syndrome)

Answer 4

epistaxis (nosebleed)

Question 5

dilated superficial blood vessels that create small, focal red lesions

Answer 5

Telangiectasia

Question 6

Vascular tumor (Giant cavernous hemangioma), thrombocytopenia, bleeding diathesis

Answer 6

Hemangioma-Thrombocytopenia Syndrome (Kasabach-Meritt Syndrome)

Question 7

Sequestration of platelets in the hemangiomas

Answer 7

Hemangioma-Thrombocytopenia Syndrome
(Kasabach-Meritt Syndrome)

Question 8

May be transmitted as an autosomal dominant, recessive, or X-linked trait.

Answer 8

Ehlers-Danlos Syndrome

Question 9

It is manifested by Hyperextensible skin, Hypermobile joints, Joint laxity

Answer 9

Ehlers-Danlos Syndrome

Question 10

Be ascribed to defects in collagen production, structure, or cross-linking, with resulting inadequacy of the connective tissues

Answer 10

Ehlers-Danlos Syndrome

Question 11

Generally applied to a group of nonthrombocytopenic purpura characterized by allergic manifestations including skin rash and edema

Answer 11

Allergic Purpura (Henoch-Schönlein Purpura)

Question 12

More appropriately applied when the conditions an acute IgA-mediated disorder

Answer 12

Allergic Purpura (Henoch-Schönlein Purpura)

Question 13

Implicates autoimmune microvascular injury

Answer 13

Allergic Purpura (Henoch-Schönlein Purpura)

Question 14

Platelet function can be inhibiting by myeloma proteins

Answer 14

Paraproteinemia

Question 15

IgA myeloma & IgG myeloma and Recurrent Purpurua

Answer 15

Dysproteinemia

Question 16

Fibrous protein consisting of rigid, linear, non-branching, aggregated fibrils

Answer 16

Amyloid

Question 17

The deposition of abnormal quantities of amyloid protein in tissues, may be primary or secondary, and localized or systemic

Answer 17

Amyloidosis

Question 18

Common in elderly men due to lack of collagen support for small blood vessels.

Answer 18

Senile Purpura

Question 19

Dark blotches are flattened. Do not blanch with pressure. Often leaving a brown stain in the skin (age spots)

Answer 19

Senile Purpura

Question 20

Deficiency of Vitamin C

Answer 20

Scurvy

Question 21

Cause defect the synthesis of collagen in the walls of small blood vessels

Answer 21

Scurvy

Question 22

“Corkscrew” hairs.

Answer 22

Scurvy