Coagulation Disorders

Question 1

Factor I

Answer 1

INHERITED COAGULOPATHIES:
- Afibrinogenemia
- Dysfibrinogenemia

ACQUIRED COAGULOPATHY
- Severe liver disease
- DIC
- Fibrinolysis

Question 2

Factor II

Answer 2

INHERITED COAGULOPATHIES
- Prothrombin deficiency

ACQUIRED COAGULOPATHY
- Liver disease
- Vitamin K deficiency
- Anticoagulant therapy

Question 3

Factor V

Answer 3

INHERITED COAGULOPATHIES
- Factor V deficiency (Owren’s disease/ Parahemophilia)

ACQUIRED COAGULOPATHY
- Severe liver disease
- DIC
- Fibrinolysis

Question 4

Factor VII

Answer 4

INHERITED COAGULOPATHIES
- Factor VII deficiency

ACQUIRED COAGULOPATHY
- Liver disease
- Vitamin K deficiency
- Anticoagulant therapy

Question 5

Factor VIII

Answer 5

INHERITED COAGULOPATHIES
- Hemophilia A
- vWD

ACQUIRED COAGULOPATHY
- DIC
- Fibrinolysis

Question 6

Factor IX

Answer 6

INHERITED COAGULOPATHIES
- Hemophilia B

ACQUIRED COAGULOPATHY
- Liver disease
- Vitamin K deficiency

Question 7

Factor X

Answer 7

INHERITED COAGULOPATHIES
- Factor X deficiency

ACQUIRED COAGULOPATHY
- Liver disease
- Vitamin K deficiency
- Anticoagulant therapy

Question 8

Factor XI

Answer 8

INHERITED COAGULOPATHIES
- Hemophilia C (Rosenthal syndrome) (common in Eastern European, Jewish descent / Ashkenazi jews)

Question 9

Factor XIII

Answer 9

INHERITED COAGULOPATHIES
- Factor XIII deficiency

ACQUIRED COAGULOPATHY
- Liver disease
- DIC
- Fibrinolysis