Vascular boo boos :(

Question 1

How does Waldenstrom’s macroglobulinemia and multiple myeloma can cause bleeding tendencies?

Answer 1

Igs coating platelets and collagen fibers

Question 2

How does the following vascular disorder effect coagulation: hereditary hemorrhagic telangiectasia

Answer 2

• Vessel walls are reduced to single layer of EC and inadequate support structures resulting in fragile vessels
• Telangiectasias: Dilated superficial vessels that will blanche (lose color with pressure, unlike petechiae
• Bleeding

Question 3

How does the following vascular disorder effect coagulation: Ehlers-Danlos Syndrome

Answer 3

• Indian rubber man (hypermobile joints and stretchy skin)
• Collagen disorder: Issues with adhesion

Question 4

How does the following vascular disorder effect coagulation: Allergic and drug-induced purpura

Answer 4

• Autoimmune vacular injury
• Drug causes development of antibody to vessel walls

Question 5

How does the following vascular disorder effect coagulation: Henoch-schonlein purpura

Answer 5

• Usually a child following upper respiratory infection
• IgA deposits in vessels: Rash, abdominal pain, joint pain, proteinuria/hematuria. Small % advance to renal disease

Question 6

How does the following vascular disorder effect coagulation: Scurvy

Answer 6

• Vitamin C deficiency
• Decreased synthesis of collagen results in weakened capillary walls

Question 7

How does the following vascular disorder effect coagulation: Senile Purpura

Answer 7

• Elderly
• Usually forearms and back of hands
• Loss of collagen and subcutaneous fat/elastic fibers to support for small blood vessels