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Clotting is my Passion > Um so fibrinolysis and coag > Flashcards

Um so fibrinolysis and coag Flashcards

1
Q

Procoagulant - what are things that participate in coagulation?

A

Platelets, vWF, coagulation factors, collagen

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2
Q

What does a deficiency in procoagulants result in?

A

BLEEDING
(except XII, Ia, PK, HMWK dysfunction)

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3
Q

Anticoagulant - what are things that participate in the regulation or inhibition of coagulation?

A

Antithrombin, Protein C, Protein S, HC II, Protein Z/ZPI, TFPI

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4
Q

What is the function of antithrombin?

A

Inactivates IIa, Xa, (IXa, XIa, XIIa, plasmin)

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5
Q

What is the function of Protein C?

A

Inactivates thrombin and thrombomodulin

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6
Q

What activates Protein C?

A

Thrombin and thrombomodulin

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7
Q

What is the function of Protein S?

A

In its free form, it is a Protein C cofactor

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8
Q

What is the function of HCII?

A

It neutralizes IIa (thrombin)

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9
Q

What is the function of TFPI?

A

Inhibits TF3/VIIa complex

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10
Q

What does a deficiency in anticoagulants result in?

A

THROMBOSIS

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11
Q

Profibrinolytic - what are things that participate in fibrinolysis?

A

Plasminogen (to plasmin), tPA, Factor XIIa, Kallikren, Urokinase

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12
Q

What is the function of Plasminogen (to plasmin)?

A

Lyses fibrin and fibrinogen and inactivates Va, VIIIa, and XIIa

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13
Q

What is the function of tPA?

A

Catalyzes the conversion of plasminogen to plasmin

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14
Q

What is the function of kallikren?

A

Formation and release of bradykinin

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15
Q

What is the function of urokinase?

A

Enzyme that converts plasminogen to plasmin

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16
Q

What does a deficiency in profibrinolytics result in?

A

THROMBOSIS

17
Q

Antifibrinolytic - what are things that participate in the regulation or inhibition of fibrinolysis?

A

PAI-1 & 2, Alpha-2 Antiplasmin, Alpha-2 Macroglobulin, TAFI, Factor XIa

18
Q

What is the function of PAI-1 & 2?

A

Neutralize tPA

19
Q

What is the function of Alpha-2 Antiplasmin?

A

Binds plasmin

20
Q

What is the function of Alpha-2 Macroglobulin?

A

Binds plasmin

21
Q

What is the function of TAFI?

A

Alters the fibrin clot so that it is less recognizable by plasmin

22
Q

What is the function of XIa?

A

Enhances TAFI production

23
Q

What does a deficiency in antifibrinolytics result in?

Clotting is my Passion (9 decks)

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