Drugs!! Blood thinners! Flashcards

1
Q

Function of anticoagulants?

A

Inhibit the coagulation cascade

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2
Q

What anticoagulants are we concerned with?

A

Coumadin/Warfarin

Heparin

Direct Thrombin Inhibitors

Direct Xa inhibitors

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3
Q

Mechanism of Coumadin/Warfarin

A

Keeps Vitamin K in storage form

Stops Vitamin K dependent factors (II, VII, IX, and X)

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4
Q

Mechanism of Heparin

A

Increase inhibitory effect of AT (antithrombin) which creates an irreversible complex with IIa, IXa, Xa, XIa, XIIa, and plasmin

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5
Q

Mechanism of Direct Thrombin Inhibitors

A

Neutralizes thrombin by binding to the active site and extending fibrin bound thrombin

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6
Q

Mechanism of Direct Xa inhibitors

A

Inhibits Factor Xa (no AT requires)

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7
Q

Function of Anti-Platelets

A

Prevents platelet aggregation

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8
Q

What drug that we are concerned with is an anti-platelet?

A

Aspirin

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9
Q

Mechanism of Aspirin

A

Inhibits cyclooxygenase to reduce TXA2 production (which stimulates activation of new platelets and increases aggregation)

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10
Q

Mechanism of thrombolytics (Fibrin specific or fibrin non-specific)

A

Dissolves the clot

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