Platelet boo boos :( Flashcards

1
Q

What is the type of disorder, defect, and laboratory results we would see in Von Willebrands (Type 1)

A

Disorder: Adhesion

Defect: vWF deficiency (all multimers)

Tests:
PFA = INC
PT = normal
APTT = INC (d/t DEC VIII_
PLT Aggregation = abnormal Ristocetin (will correct with addition of NP)

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2
Q

What is the type of disorder, defect, and laboratory results we would see in Bernard-Soulier

A

Disorder: Adhesion

Defect: Lack of Gp1b

Tests:
PFA = INC
PLT = DEC
Large PLT
PLT Aggregation = abnormal Ristocetin

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3
Q

What is the type of disorder, defect, and laboratory results we would see in Glanzmann’s

A

Disorder: Aggregation

Defect: Lack GPIIb and GPIIIa

Tests:
PFA = INC
PT = normal
APTT = normal
PLT count = normal
PLT aggregation = normal ONLY w/Ristocetin

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4
Q

What is the type of disorder, defect, and laboratory results we would see in Delta Storage Pool

A

Disorder: Release

Defect: Lack of dense granules

Tests:
Hypo or agranular plts

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5
Q

What is the type of disorder, defect, and laboratory results we would see in Gray Platelet

A

Disorder: Release

Defect: Marked DEC in platelet alpha granules

Tests:
Hypo or agranular plts

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6
Q

What is the type of disorder, defect, and laboratory results we would see in ITP

A

Disorder: Thrombocytopenia

Defect: Spontaneous – adults/AIDS; kids/immunization

Tests:
PFA = INC
PLT count = LOW <20,000
Large plt (variable)
BM = megakaryocyte hyperplasia
Deficient clot retraction

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7
Q

What is the type of disorder, defect, and laboratory results we would see in TTP

A

Disorder: Thrombocytopenia

Defect: Autoantibody against ADAMTS13, vWF cannot break apart

Tests:
- Hemolytic anemia with schistocytes
- Thrombocytopenia/hemorrhage
- Fluctuating neurological dysfunction
- Fever
- Progressive renal disease

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8
Q

What is the type of disorder, defect, and laboratory results we would see in HUS

A

Disorder: Thrombocytopenia

Defect: Resembles TTP with NO neurologic symptoms. Plts are sequestered in kidney

Tests:
- MAHA
- thrombocytopenia
- acute renal failure (RBCs, protein, and casts in urine)

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9
Q

What is the type of disorder, defect, and laboratory results we would see in HELLP

A

Disorder: Thrombocytopenia

Defect: Release of TXA2. Microvascular endothelial damage. Vascular lesions. Intravascular plt activation

Tests:
- Hemolysis: hgb/hct, LDH, bili, Hapt, schisto
- PLT count = LOW <200,000
- Hepatic dysfunction (AST >42, ALT >24, LDH >164)

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10
Q

What is the type of disorder, defect, and laboratory results we would see in drug induced thrombocytopenia

A

Disorder: thrombocytopenia

Defect: Antibody complex attaches to platelet

Tests:
- Plt count LOW
- Test for the presence of heparin-induced ab in the patient plasma (use a plt aggregometer; if ab is present, plts will aggregate)

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