Platelet boo boos :( Flashcards
What is the type of disorder, defect, and laboratory results we would see in Von Willebrands (Type 1)
Disorder: Adhesion
Defect: vWF deficiency (all multimers)
Tests:
PFA = INC
PT = normal
APTT = INC (d/t DEC VIII_
PLT Aggregation = abnormal Ristocetin (will correct with addition of NP)
What is the type of disorder, defect, and laboratory results we would see in Bernard-Soulier
Disorder: Adhesion
Defect: Lack of Gp1b
Tests:
PFA = INC
PLT = DEC
Large PLT
PLT Aggregation = abnormal Ristocetin
What is the type of disorder, defect, and laboratory results we would see in Glanzmann’s
Disorder: Aggregation
Defect: Lack GPIIb and GPIIIa
Tests:
PFA = INC
PT = normal
APTT = normal
PLT count = normal
PLT aggregation = normal ONLY w/Ristocetin
What is the type of disorder, defect, and laboratory results we would see in Delta Storage Pool
Disorder: Release
Defect: Lack of dense granules
Tests:
Hypo or agranular plts
What is the type of disorder, defect, and laboratory results we would see in Gray Platelet
Disorder: Release
Defect: Marked DEC in platelet alpha granules
Tests:
Hypo or agranular plts
What is the type of disorder, defect, and laboratory results we would see in ITP
Disorder: Thrombocytopenia
Defect: Spontaneous – adults/AIDS; kids/immunization
Tests:
PFA = INC
PLT count = LOW <20,000
Large plt (variable)
BM = megakaryocyte hyperplasia
Deficient clot retraction
What is the type of disorder, defect, and laboratory results we would see in TTP
Disorder: Thrombocytopenia
Defect: Autoantibody against ADAMTS13, vWF cannot break apart
Tests:
- Hemolytic anemia with schistocytes
- Thrombocytopenia/hemorrhage
- Fluctuating neurological dysfunction
- Fever
- Progressive renal disease
What is the type of disorder, defect, and laboratory results we would see in HUS
Disorder: Thrombocytopenia
Defect: Resembles TTP with NO neurologic symptoms. Plts are sequestered in kidney
Tests:
- MAHA
- thrombocytopenia
- acute renal failure (RBCs, protein, and casts in urine)
What is the type of disorder, defect, and laboratory results we would see in HELLP
Disorder: Thrombocytopenia
Defect: Release of TXA2. Microvascular endothelial damage. Vascular lesions. Intravascular plt activation
Tests:
- Hemolysis: hgb/hct, LDH, bili, Hapt, schisto
- PLT count = LOW <200,000
- Hepatic dysfunction (AST >42, ALT >24, LDH >164)
What is the type of disorder, defect, and laboratory results we would see in drug induced thrombocytopenia
Disorder: thrombocytopenia
Defect: Antibody complex attaches to platelet
Tests:
- Plt count LOW
- Test for the presence of heparin-induced ab in the patient plasma (use a plt aggregometer; if ab is present, plts will aggregate)