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Clotting is my Passion > Balance Beam > Flashcards

Balance Beam Flashcards

1
Q

List the things that participate in PROcoagulation

A

Platelets
vWF
Coagulation Factors

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2
Q

What results from a deficiency in PROCOAGULANTS

A

Bleeding

(EXCEPT XII, Ia, PK, HMWK Dysfunction)

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3
Q

List the things that participate in ANTIcoagulation

A

Antithrombin
Protein C
Protein S
HC II
Protein Z/ZPI
TFPI

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4
Q

What things that participate in ANTIcoagulation are vitamin K dependent?

A

Protein C, Protein S, and Protein Z/ZPI

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5
Q

What does a deficiency in ANTICOAGULANTS result in?

A

Thrombosis

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6
Q

What is the function of antithrombin?

A

Inactivates IIa and Xa mainly

(Also IXa, XIa, XIIa, plasmin)

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7
Q

What is the function of protein C

A

Inactivates Va and VIIIa as well as liberates tPA

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8
Q

What is the function of Protein S?

A

Free form is a cofactor for APC. Protein C needs Protein S

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9
Q

What is the function of HCII

A

Neutralize IIa (thrombin)

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10
Q

What is the function of Protein Z/ZPI

A

Degrades Xa (ZPI - also XIa)

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11
Q

What is the function of TFPI?

A

Inhibits TF3/VIIa (ext tenase) complex

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12
Q

What are things that are involved in ANTIFIBRINOLYTIC activity?

A

PAI-1 and 2
Alpha-2 Antiplasmin
Alpha-2 Macroglobulin
TAFI
Factor XIa

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13
Q

What does a deficiency in antifibrinolytics result in?

A

Bleeding

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14
Q

What is the function of PAI 1 and 2?

A

Neutralize tPA

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15
Q

What is the function of Alpha-2 Antiplasmin

A

Binds plasmin

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16
Q

What is the function os Alpha-2 Macroglobulin

A

Binds Plasmin

17
Q

What is the function of TAFI

A

Alters the fibrin clot so that it is less recognizable by plasmin

18
Q

What is the function of Factor XIa?

A

Enhances TAFI production

19
Q

What are things involved in PROFIBRINOLYTIC activity?

A

Plasminogen
tPA
Factor XIIa
Kallikren
Urokinase

20
Q

What does a deficiency in things that are profibrinolytic activity result in?

A

Thrombosis

21
Q

What is the function of plasminogen (to plasmin)

A

Lyses fibrin and fibrinogen
Inactivates Va, VIIIa, XIIa. It breaks XIIa into fragments

22
Q

What is tPA?

A

Tissue plasminogen activator from endo

Clotting is my Passion (9 decks)

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