Balance Beam Flashcards
List the things that participate in PROcoagulation
Platelets
vWF
Coagulation Factors
What results from a deficiency in PROCOAGULANTS
Bleeding
(EXCEPT XII, Ia, PK, HMWK Dysfunction)
List the things that participate in ANTIcoagulation
Antithrombin
Protein C
Protein S
HC II
Protein Z/ZPI
TFPI
What things that participate in ANTIcoagulation are vitamin K dependent?
Protein C, Protein S, and Protein Z/ZPI
What does a deficiency in ANTICOAGULANTS result in?
Thrombosis
What is the function of antithrombin?
Inactivates IIa and Xa mainly
(Also IXa, XIa, XIIa, plasmin)
What is the function of protein C
Inactivates Va and VIIIa as well as liberates tPA
What is the function of Protein S?
Free form is a cofactor for APC. Protein C needs Protein S
What is the function of HCII
Neutralize IIa (thrombin)
What is the function of Protein Z/ZPI
Degrades Xa (ZPI - also XIa)
What is the function of TFPI?
Inhibits TF3/VIIa (ext tenase) complex
What are things that are involved in ANTIFIBRINOLYTIC activity?
PAI-1 and 2
Alpha-2 Antiplasmin
Alpha-2 Macroglobulin
TAFI
Factor XIa
What does a deficiency in antifibrinolytics result in?
Bleeding
What is the function of PAI 1 and 2?
Neutralize tPA
What is the function of Alpha-2 Antiplasmin
Binds plasmin
What is the function os Alpha-2 Macroglobulin
Binds Plasmin
What is the function of TAFI
Alters the fibrin clot so that it is less recognizable by plasmin
What is the function of Factor XIa?
Enhances TAFI production
What are things involved in PROFIBRINOLYTIC activity?
Plasminogen
tPA
Factor XIIa
Kallikren
Urokinase
What does a deficiency in things that are profibrinolytic activity result in?
Thrombosis
What is the function of plasminogen (to plasmin)
Lyses fibrin and fibrinogen
Inactivates Va, VIIIa, XIIa. It breaks XIIa into fragments
What is tPA?
Tissue plasminogen activator from endo
