Vaping, Marijuana, CBD

Question 1

Concerns with nicotine addiction/vaping in adolescents

Answer 1

nicotine interferes with maturation of pre-frontal cortex (impaired neuroplasticity, long term cognitive impairment, behavioral disturbances later in life)

Question 2

possible cause of vaping injury

Answer 2

bad ingredients (VITAMIN E ACETATE)

Question 3

How do endocannabinoids travel in the neural cleft?

Answer 3

IN REVERSE: endocannabinoids are synthesized in post synaptic neuron and activate the CB1R on the presynaptic neuron

Question 4

What does stimulation of CB1 receptor (by THC) cause?

Answer 4

inhibition of adenylyl cyclase and hyper polarization of the neuron

Question 5

Enzyme that breaks down anandamide?

Answer 5

FAAH: fatty acid amine hydrolase

Question 6

Effect of decreased breakdown of anandamide

Answer 6

analgesia (FAAH inhibitors are area of study)

Question 7

Dronabinol class

Answer 7

synthetic delta-9-THC

Question 8

Dronabinol indications (3)

Answer 8

1) anorexia in AIDS patients
2) chemotherapy induced N/v
3) moderate to severe sleep apnea

Question 9

CBD absorption

Answer 9

erratic GI absorption with significant first pass metabolism (6% oral bioavailability)

Question 10

How is CBD metabolized

Answer 10

7 CYPs in the liver

Question 11

Receptors CBD is agonist to (3)

Answer 11

1) TRPV1 (capsaicin receptor)
2) PPAR-gamma (glitizone receptor)
3) serotonin receptor

Question 12

Describe use of Epidiolex

Answer 12

FDA approved treatment of rare-childhood epilepsies in people 2+ y/o (Dravet syndrome, Lennox-Gastaut syndrome)

Question 13

CBD classification

Answer 13

oral CBD solution

Question 14

legality of CBD (2)

Answer 14

1) hemp CBD legal to sell as cosmetic ingredient

2) illegal to sell as food, dietary supplement, or animal feed

Question 15

How is CBD distributed in the body?

Answer 15

rapidly distributes and accumulates in adipose tissue