CNS Stimulants (Iszard) Flashcards

1
Q

Basic action of stimulants

A

enhance neurotransmitter transmission by serving as direct and indirect non-catecholamine sympathomimetics

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2
Q

normal side effects of stimulants (6)

A
  • dyspepsia/GI distress
  • headache
  • decreased appetite
  • insomnia
  • anxiety
  • elevated BP/HR
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3
Q

rare side effects of stimulants (5)

A
  • priapism
  • seizures
  • sudden cardiac death
  • stroke/MI
  • chemical leukoderma (with patch use)
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4
Q

onset of activity of stimulants

A

24 hours in most patients

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5
Q

Prescribing stimulants

A

stimulants are CONTROLLED SUBSTANCES (1 month supply only, no refills, no samples)

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6
Q

Immediate release amphetamine-based stimulant that comes in LIQ form

A

Dextroamphetamine sulfate/Procentra

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7
Q

Extended release amphetamine-based stimulant that comes in LIQ form

A

Amphetamine/Dyanavel XR

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8
Q

Oral disintegrating tab form of amphetamine

A

Adzenyz XR-ODT

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9
Q

immediate release, methylphenidate-based stimulant in LIQ form

A

Methylphenidate/Methylin Oral Solution

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10
Q

extended release, methylphenidate-based stimulant in transdermal patch form

A

methylphenidate transdermal/daytrana

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11
Q

extended release, methylphenidate-based stimulant in chewable tablet form

A

methylphenidate HCL/QuilliChew

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12
Q

extended release, methylphenidate-based stimulant in liquid form

A

methylphenidate/Quillivant XR

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13
Q

MOA non-stimulants (for ADHD)

A

enhance neurotransmitter transmission via:

1) inhibition of NE pre-synaptic reuptake
2) agonists of CNS alpha-2 adrenergic receptors

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14
Q

onset of activity for non-stimulants

A

1-4+ weeks

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15
Q

When to use non-stimulants

A

useful for patients intolerant of stimulant effects or parents/patients resistant to using stimulant-class

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16
Q

Non-stimulant medication in CAP form that has a risk of suicidal thoughts

A

Atomoxetine/Strattera (Extended release)

17
Q

Non-stimulant medications in TAB form that are anti-hypertensives (2)

A

1) Clonidine

2) Guanfacine

18
Q

Nonstimulant/Anti-hypertensives MOA

A

alpha-2 agonists

19
Q

What is the risk with discontinuation of non stimulant/antihypertensives?

A

Risk of rebound HTN if they are not discontinued with a downward dose titration over 1+ weeks