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Year2 Repro exam I > Vaginal Path III > Flashcards

Vaginal Path III Flashcards

1
Q

how does invasice SCC of the vulva present

A

nodules/masses wiht background of leukoplakia

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2
Q

majority of invasice vulvar carcinomas are what type

A

SCC

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3
Q

majority SCC of vulva is what pattern

A

warty and bowenoid (HPV)
repro- age women
assoc with HPV 16 18 but also type 33

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4
Q

ulcerated mass on vulva, next step?

A

malignant until proven otherwise

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5
Q

what is the pattern of SCC of vulva that presents in elderly women (mid 70s)

A

keratinizing type (not HPV)

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6
Q

precursor leasions to keratinizing SCC of the vulva

A

long stnading LS&A and chronic inflammation

VIN simplex or differentiated (not HPV)

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7
Q

which type SCC of the vulva is HPV releated

A

the warty bowenoid type that is seen in younger women

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8
Q

describe spread of lymph invasion starting in vulva

A

inguinal to pelvic to iliac to para-aortic

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9
Q

Tx SCC of vulva

A

vulvectomy and lymphadenectomy

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10
Q

the deeper the invasion of SCC of the vulva corresponds to what

A

chance of inguinal metastasis

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11
Q

gross findings of SCC of the vulva

A

exophytic mass or endophytic ulcer or both
can be labia minor or majora
10% multifocal when assoc with condyloma

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12
Q

keratin pearls are seen in bx taken from vulvular lesion

A

invasive SCC

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13
Q

stage 1 SCC carcinoma prognosis?
stage 3?
4?

A

1: 80% 5 yr
3: 40% 5 yr
4: 10% 5 yr

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14
Q

where does accessory breast tissue form

A

along the milk line, extending to vulva

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15
Q

what is a papillary hidradenoma

A

sharply circumscribed nodule in vulva with normal overlying skin
considered a benign tumor from apocrine glands

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16
Q

pruritic red crusted sharply demarcated area on labia majora in elderly woman

A

extramammary paget disease

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17
Q

is there an underlying carcinoma tumor mass in paget disease of the vulva

A

no

18
Q

what do papillary hidradenomas feel like

A

nodule that is moveable

19
Q

histo from vulva shows double layer of columnar/myoepithelial cells

A

papillary hidradenoma

20
Q

extramammary paget dsease thought to arise from what

A

primitive germline cells of mammary like gland ducts in vulvar skin

21
Q

what do paget cells look like

A

halo cells

epidermal appendegaes

22
Q

what can you stain paget cells with

A

PAS +, mucin +
CEA+
EMA + on IHC stain
(S100 and Melanin A negative)

23
Q

Tx for extramammary paget disease

A

wide local excision
may recur
Need to look for synchronous tumors

24
Q

what type of melanoma is typical on vulva

A

nodular type

25
Q

cytologic stains to use for malignant melanoma of vulva

A

S100 and melanin A +

26
Q

pagetoid histology is what and seen when

A

pattern of individual clear cells infiltrating through epidermis
also seen in melanoma

27
Q

see discoloration of vulva

next step

A

biopsy

have to rule out melanoma

28
Q

when is the glandular epithelium of embryo vagina replced by squamous epithelium

A

18 weeks

29
Q

what historically caused vaginal adenosis

A

DES when women were given this with miscarriages

30
Q

women given DES for miscarriages could have daughters with what cancer

A

clear cell carcinom of the vagina

31
Q

DES exposure in males increases risk for what

A

cryptorchism and hypospadius

32
Q

SCC of vulva arises from what

A

Vaginal Intraepithelial neoplasm

33
Q

Prognosis SCC depends on what

A

size and nodal spread

34
Q

What is embryonal rhabdomyosarcoma

A

neoplasm of girls <3 cm

grows by local invasion with spread to nodes at distant sites

35
Q

where do gartner duct cysts arise from

A

wolffian remnant on lateral vaginal wall

36
Q

path of a gartner duct cyst

A

simple cyst with monolayer of benign cuboidal epithelium

37
Q

Tx of gartner duct cyst

A

excisional Bx

38
Q

what does histo of clear cell carcinoma of the vagina look like

A

vacuolated tumor cells with gland formation

39
Q

what tumor looks like a grape cluster

A

embryonal rhabdomyosarcoma

40
Q

embryonal rhabdomyosarcoma are often misDx as what

A

inflammatory polyp

41
Q

tumor cells show elongated muscle cells with cross striations?

A

embryonal rhabdomyosarcoma

Year2 Repro exam I (19 decks)

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