Phys review, michels Flashcards

(55 cards)

1
Q

when the corpus luteum sheds what happens to E and P levels? pituitary?

A

E and P drop

pituitary then increases FSH

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2
Q

increasing FSH stimulates what response in menstrual cycle

A

recruits large antral follicles to grow and they begin to secrete low amounts of E and inhibin

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3
Q

How do E and inhibin affect FSH

A

negative feedback

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4
Q

what occurs with declining FSH levels

A

atresia of all but 1 follicle that will now secrete high levels E

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5
Q

how does high E affect gonadotrophs

A

LH and some FSH surgres

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6
Q

LH surge causes what

A

metabolic maturation, ovulation, leutinization

corpus luteum now makes high P and some E and inhibin

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7
Q

response to high P and E and inhibin levels

A

negative feedback to LH and FSH returning to basal levels

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8
Q

if LH levels remain at basal level what will happen to corpus luteum

A

will die

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9
Q

3 stages of follicular development

A

initiation and gonadotropin independent phase
basal growth phase
rapid growth phase

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10
Q

what follicles are not dependent on pituitary gland

A

primordial, and primary

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11
Q

how many days is the rapid growth phase from large antral to dominant follicle

A

14 days

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12
Q

hormone producing cells

A

theca cells

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13
Q

what cells form corpus luteum

A

mural granulosa cells and theca cells

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14
Q

before ovulation what phase does the primary oocyte undergo

A

from prophase I to arrest in metaphase II

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15
Q

when does the secondary oocyte complete meiosis

A

at fertilization

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16
Q

at follicular phase what does GnRH do

A

pulsatile to stimulate LH act on theca cells and FSH act on granulosa cells

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17
Q

at end of follicular phase why is there LH surge

A

high levels E gives + feedback

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18
Q

what happens to theca cells and granulosa cells in luteal phase

A

theca still respond to LH
granulosa now respond to FSH AND LH
both types cells become luteal cells that secrete P and E

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19
Q

feedback from E and P in luteal phase

A

negative feedback

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20
Q

what are corpus albican

A

scar tissue in ovary form recent regression of corpus luteum

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21
Q

what are the parts of fallopian tube

A

infundibulum is opening
ampulla- fertilization takes place
isthmus
intramural segment (proximal)

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22
Q

estrogen effects on oviduct

A
increase endosalpinx epithelial size
increase blood flow
increase glycoproteins
increase ciliogenesis
increase mucus and muscular tone
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23
Q

progesterone effects on oviducts

A

dec epithelial size
dec mucus
relax muscular tone
deciliation

24
Q

phases of menstrual cycle

A

menstrual phase
proliferative phase
secretory phase

25
LH surge corresponds to what event
ovulation
26
effects of E on cervical mucus
stimulates production of thin watery alkaline mucus
27
effects of P on cervical mucus
stimulates production of scant viscous, slightly acidic mucus
28
E effecs on bone
closure of epiphyseal plates | anabolic and calcitropic hormone
29
E effects on liver
increase LDL R and HDL levels, cortisol binding protein, thyroid hormone binding protein and sex hormone binding protein
30
CV effects of E
E cause vasodilation through NO synthesis
31
what does E bind to
majoirty sex hormone binding protein | also albumin
32
P binds to what
cortisol binding protein and albumin
33
how many days after ovulation dose hCG increase in pregnancy
10 days
34
duration of pregnancy is counted from what start date
date of last menstual cycle
35
how many weeks is a pregnancy counted from ovulation
38 weeks
36
main hormone in 1st trimester
hCG which rescues corpus luteum and stimulates corpus luteal production of estrogen and progesterone
37
main hormone in 2nd and 3rd trimesters
P and E under control of placenta
38
what are limits of placenta in hormone production
cannot make adequate cholesterol | lacks enzymes for estrone and estradiol and estriol
39
what does the mother contribute to placenta for hormone synthesis
LDL cholesterol
40
what does the fetus contribute to placenta for hormone synthesis
enzymes to make estriol | enzymes are in adrenal glands and liver
41
what is HPL
human placental lactogen | similar to GH and PRL
42
what hormone is directly proportional to size of placenta
human placental lactogen
43
effects of hPL
diabetogenic (antagonist to insulin) increase glucose availability for fetus simulates mammary growth and development
44
what happens to pituiatry in pregnancy
doubles in size | ADH set point is lowered
45
what happens to adrenal gland in pregnancy
cortisol and aldosterone levels increase | E stimulates RAAS
46
thyroid changes in pregnangcy
total T4 and T3 increase but free T4 normal | TSH decrease in first trimester
47
CV changes in pregnancy
icnreased volume dec peripheral R increase SV, HR, CO and contractility
48
Resp changes in pregnancy
increase minute and tidal volume dec PCO2, dec FRC, dec IRV respiratory alkalosis
49
renal changes in pregnancy
increase ADH, renin, ANG II, aldosterone, GFR
50
stages of labor
strong uterine contractions delivery of fetus delivery of placenta
51
what hormones initiate parturition
placental CRH E oxytocin PGs
52
PRL levels during breast feeding
pulsatile
53
what releases oxytocin
pars nervosa
54
how come women who are breast feeding don't ovulate
the increased prolactin levels neg feedback to the parvicellular cells which decrease GnRH which dec LH and FSH production so amenorrhea
55
roles of oxytocin
milk letdown but also limits bleeding during partuition